Lung Transplant Hazard May Rise with Obese Recipients, Smoking Donors

Study found more 'primary graft dysfunction,' which is tied to higher death risk Source: HealthDay Related MedlinePlus Pages: Lung Transplantation, Obesity
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
n O Abstract BACKGROUND: An obesity paradox, wherein obese patients have lower mortality, has been described in cardiopulmonary diseases, including pulmonary arterial hypertension (PAH). Our objective was to determine whether obesity and body mass index (BMI) are associated with mortality in patients with PAH. METHODS: We assessed incident patients with idiopathic, drug-induced, and heritable PAH from the French PAH Registry. Cox regression and Kaplan-Meier analysis were used to assess the association between BMI and obesity with all-cause mortality. RESULTS: Of 1255 patients included, 30% were obese. A ...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Leptin is secreted by adipocytes, induces satiety via central mechanisms, and stimulates lipolysis and fatty acid utilization. Cardiac cachexia has been associated with worse outcomes in chronic heart failure (HF), and the role of leptin is poorly understood. We hypothesized that patients in chronic HF with low leptin levels would have worse outcomes and that leptin would modify the relationship of body mass index (BMI) with HF progression.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The obesity paradox in heart failure indicates that overweight and obese patients have better survival compared to those with normal BMI. However, little is known about the impact of BMI in patients supported by CF-LVAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Body mass index (BMI)
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Device infections still remains a frequent complication after continuous flow left ventricular assist device (CF-LVAD) implantation. Although obesity has been demonstrated to be a significant risk factor for mortality in patients undergoing heart transplantation, there is a paucity of data on the effect of obesity on outcomes in patients undergoing CF-LVAD implantation. The purpose of this study was to analyze the effect of obesity on outcomes after CF-LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Donor body-mass index (BMI) has been increasing over time, although donor BMI remains lower on average than heart transplant recipient BMI. There is limited data regarding the use of allograft hearts from donors with obesity. Our purpose was to assess the outcome of performing heart transplantation from donors with BMI> 35 kg/m2.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Bariatric surgery is a well documented surgical procedure for achieving substantial weight loss in morbidly obese patients. However, there is a paucity of data examining its safety and efficacy in patients with continuous flow left ventricular assist devices (CF-LVADs) as a mechanism to achieve adequate weight loss for purposes of being considered for heart transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
High body mass index (BMI) is associated with increased risk of acute cellular rejection (ACR) in renal and cardiac transplant recipients. Despite advances in immunosuppressive therapies, ACR continues to occur in more than a third of recipients in the first year post lung transplant (LTx). Although there is data on the association between primary graft dysfunction and obesity in LTx, the effect of BMI on the incidence of ACR has not been examined.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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