Update in pediatric nasopharynx undifferentiated carcinoma.
Update in pediatric nasopharynx undifferentiated carcinoma. Br J Radiol. 2019 Jul 19;:20190107 Authors: Claude L, Jouglar E, Duverge L, Orbach D Abstract Many of the principles established in adults with undifferentiated nasopharyngeal carcinoma (NPC) apply to children, adolescents and young adults (AYA). However, NPC in young patients should be distinguished from the adult form by several points. This review focuses mainly on differences between adult and pediatric NPC. The role of biology and genetics in pediatric NPC is discussed. Systemic treatment modalities including type of chemotherapy induction, timing of treatment, role of immunotherapy as adjuvant treatment, or in relapsing/ metastatic diseases are reported. Radiation modalities (doses, techniques…) in children are also reviewed. Long-term effects including secondary cancers are finally be discussed in this young NPC population. PMID: 31322911 [PubMed - as supplied by publisher]