Radiation induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours.

Radiation induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours. Br J Radiol. 2019 Jul 19;:20190028 Authors: Kountouri M, Pica A, Walser M, Albertini F, Bolsi A, Kliebsch U, Bachtiary B, Combescure C, Lomax AJ, Schneider R, Weber DC Abstract OBJECTIVES: To assess the radiation-induced optic neuropathy (RION) prevalence, following high dose pencil beam scanning proton therapy (PBS PT) to skull base and head and neck (H&N) tumours. METHODS: Between 1999 and Between , 2014 and Between , 216 adult patients, median age 47 years (range, 18-77), were treated with PBS PT for skull base or H&N malignancies, delivering ≥45 GyRBE to the optic nerve(s) (ON) and/or optic chiasma (OC). The median administered dose to the planning target volume (PTV) was 74.0 GyRBE (range, 54.0-77.4). The median follow-up was 5.3 years (range, 0.8-15.9). RESULTS: RION was observed in 14 (6.5%) patients at a median time of 13.2 months (range, 4.8-42.6) following PBS PT. Most (92.9%) of RION were symptomatic. Most affected patients (11/14; 79%) developed unilateral toxicity. Grade 4, 3, 2 and 1 toxicity was observed in 10, 2, 1 and 1 patients, respectively. On univariate analyses, age (
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research

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