Radiation induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours.
Radiation induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours. Br J Radiol. 2019 Jul 19;:20190028 Authors: Kountouri M, Pica A, Walser M, Albertini F, Bolsi A, Kliebsch U, Bachtiary B, Combescure C, Lomax AJ, Schneider R, Weber DC Abstract OBJECTIVES: To assess the radiation-induced optic neuropathy (RION) prevalence, following high dose pencil beam scanning proton therapy (PBS PT) to skull base and head and neck (H&N) tumours. METHODS: Between 1999 and Between , 2014 and Between , 216 adult patients, median age 47 years (range, 18-77), were treated with PBS PT for skull base or H&N malignancies, delivering ≥45 GyRBE to the optic nerve(s) (ON) and/or optic chiasma (OC). The median administered dose to the planning target volume (PTV) was 74.0 GyRBE (range, 54.0-77.4). The median follow-up was 5.3 years (range, 0.8-15.9). RESULTS: RION was observed in 14 (6.5%) patients at a median time of 13.2 months (range, 4.8-42.6) following PBS PT. Most (92.9%) of RION were symptomatic. Most affected patients (11/14; 79%) developed unilateral toxicity. Grade 4, 3, 2 and 1 toxicity was observed in 10, 2, 1 and 1 patients, respectively. On univariate analyses, age (
' There's once again excitement about renal artery denervation and … it's justified,'says one cardiologist, while another hopes for FDA approval next year, and a third is'still not 100% convinced. 'theheart.org on Medscape
Conditions: Pulmonary Arterial Hypertension; Right-Sided Heart Failure Intervention: Other: PET/MRI Sponsors: University of Wisconsin, Madison; United Therapeutics Recruiting
Publication date: Available online 15 September 2019Source: The LancetAuthor(s): Rajiv Agarwal, Patrick Rossignol, Alain Romero, Dahlia Garza, Martha R Mayo, Suzette Warren, Jia Ma, William B White, Bryan WilliamsSummaryBackgroundSpironolactone is effective at reducing blood pressure in patients with uncontrolled resistant hypertension. However, the use of spironolactone in patients with chronic kidney disease can be restricted by hyperkalaemia. We evaluated use of the potassium binder patiromer to allow more persistent use of spironolactone in patients with chronic kidney disease and resistant hypertension.MethodsIn this ...
CONCLUSION: The entire field of acute stroke care has been revolutionized in the last 60 years. Big data management, telemedicine, software, new brain and vascular imaging techniques, biomarkers, robotics etc., are currently in development and again should lead to new and surprising changes during the next decades. PMID: 31521397 [PubMed - as supplied by publisher]
CONCLUSION: In LCC, the clinical spectrum is largely heterogeneous and the course of the disease appears highly variable in contrast to other hereditary cerebral small vessel diseases. PMID: 31521395 [PubMed - as supplied by publisher]
Authors: Liebenthal R, Butler S, Coppola J, Shah B Abstract BACKGROUND: Use of a universal diagnostic catheter may decrease procedural time and catheter-exchange related spasm when compared with a dual-catheter strategy. The aim of this study was to identify preprocedural predictors of failure to complete a coronary angiogram with a universal catheter alone. METHODS: Consecutive patients (n = 782) who underwent a right transradial/transulnar coronary angiogram with a single operator were retrospectively reviewed. Multivariable predictors of failure to complete the procedure with a universal catheter alone were ...
In principle, genetic variants associated with longevity should help to point out which processes are more important in the aging process, and therefore steer researchers towards more effective approaches to interventions aimed at slowing or reversing aging. In practice, however, so few longevity-associated variants have been found that little has been accomplished on this front. One of them is examined in this open access paper. The mechanism by which it contributes to longevity may be a reduction in the burden of hypertension and consequent tissue damage. To be clear, near any study of genetics and aging turns up ...
CONCLUSIONS: TM was associated with within-group (but not between-groups) improvements in BP. Continued research using randomized controlled trials with larger samples, and measuring psychophysiological outcomes at longer follow-up intervals is recommended. PMID: 31519275 [PubMed - in process]
HIGH blood pressure is a common condition in the UK, with more one in four people living with it. It is well understood that maintaining an active lifestyle can help to lower a person ’s reading. One study suggests a certain exercise may play a role in reducing high blood pressure.
ConclusionsThese findings suggest an association between theeNOS c.-813C>T polymorphism and the development of proteinuria in mBC patients receiving a bevacizumab-based chemotherapy.