Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4

Conclusions
Epigenetic modification of miR-429 can manipulate liver T-ICs by targeting the RBBP4/E2F1/OCT4 axis. This miRNA might be targeted to inactivate T-ICs, thus providing a novel strategy for HCC prevention and treatment.

Source: Gut - December 8, 2014 Category: Gastroenterology Authors: Li, L., Tang, J., Zhang, B., Yang, W., LiuGao, M., Wang, R., Tan, Y., Fan, J., Chang, Y., Fu, J., Jiang, F., Chen, C., Yang, Y., Gu, J., Wu, D., Guo, L., Cao, D., Li, H., Cao, G., Wu, M., Zhang, M. Q., Chen, L., Wang, H. Tags: Hepatic cancer Hepatology Source Type: research