A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS

Conclusions
DPYD harbours rare and common capecitabine toxicity variants. The toxicity polymorphism in the TYMS region may actually act through ENOSF1.

Source: Gut - December 8, 2014 Category: Gastroenterology Authors: Rosmarin, D., Palles, C., Pagnamenta, A., Kaur, K., Pita, G., Martin, M., Domingo, E., Jones, A., Howarth, K., Freeman-Mills, L., Johnstone, E., Wang, H., Love, S., Scudder, C., Julier, P., Fernandez-Rozadilla, C., Ruiz-Ponte, C., Carracedo, A., Castellvi Tags: Open access, Colon cancer Source Type: research