XIAP variants in male Crohn's disease

Conclusions This study reveals the unanticipated, frequent occurrence of XIAP variants in male paediatric-onset CD. The link between XIAP and NOD1/2, and the association of XIAP variants with XLP2, support the concept of PID in a subset of IBD patients. Moreover, these studies provide a rationale for the implementation of XIAP sequencing in clinical diagnostics in male patients with severe CD.
Source: Gut - Category: Gastroenterology Authors: Tags: Crohn's disease, Editor's choice Inflammatory bowel disease Source Type: research