XIAP variants in male Crohn's disease
Conclusions
This study reveals the unanticipated, frequent occurrence of XIAP variants in male paediatric-onset CD. The link between XIAP and NOD1/2, and the association of XIAP variants with XLP2, support the concept of PID in a subset of IBD patients. Moreover, these studies provide a rationale for the implementation of XIAP sequencing in clinical diagnostics in male patients with severe CD.
Source: Gut - Category: Gastroenterology Authors: Zeissig, Y., Petersen, B.-S., Milutinovic, S., Bosse, E., Mayr, G., Peuker, K., Hartwig, J., Keller, A., Kohl, M., Laass, M. W., Billmann-Born, S., Brandau, H., Feller, A. C., Rocken, C., Schrappe, M., Rosenstiel, P., Reed, J. C., Schreiber, S., Franke, A Tags: Crohn's disease, Editor's choice Inflammatory bowel disease Source Type: research