Self-assembly of mixed systems based on nonionic and carbamate-bearing cationic surfactants as a tool for fabrication of biocompatible nanocontainers

Publication date: Available online 20 July 2019Source: Journal of Molecular LiquidsAuthor(s): Alla B. Mirgorodskaya, Rushana A. Kushnazarova, Svetlana S. Lukashenko, Lucia Ya. ZakharovaAbstractAggregation behavior of mixed micellar solutions and microemulsions based on cationic carbamate-bearing surfactants with hexadecyl hydrophobic group and nonionic surfactants (Tween 80, Tween 20, and Triton X 100) has been studied. Critical micelle concentrations have been determined at varying component ratios, which demonstrated a negative deviation of surfactant systems from ideal behavior (synergetic effect). The electrokinetic potential and size of aggregates have been evaluated. Solubilizing effect of individual and mixed systems toward anti-inflammatory drug meloxicam possessing pH dependent solubility in aqueous solutions has been testified by spectrophotometry. It has been determined that nonionic surfactants slightly increase the solubility of meloxicam in water, while the carbamate-bearing surfactants with the concentration of nearly 0.1% provide more than a 10-fold increase in the solubility of this drug in weakly acidic media. Carbamate-bearing surfactants are referred to a class of moderately toxic substances. Their employment in binary compositions with nonionic surfactants has decreased the toxicity of the systems with the retention of the high degree of solubilizing effect. A transition to biocompatible Tween 80/oleic acid/water/ethyl alcohol microemulsions modified with...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research

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Authors: Abedi B, Reardon S, Winters KC, Lee S Abstract The present study used data from a randomized controlled trial on brief interventions with adolescents to identify distinct longitudinal patterns of substance use and identify predictors, as well as outcomes associated with those use patterns. Data were originally collected for the purpose of evaluating two brief intervention conditions with adolescents who had been identified in a school setting as abusing alcohol or other drugs (total sample, N = 315). Adolescents were randomly assigned to a two-session adolescent only brief intervention (BI-A), a two-sessio...
Source: Journal of Child and Adolescent Substance Abuse - Category: Addiction Tags: J Child Adolesc Subst Abuse Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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