Predictors of high hospital care and medication costs and cost trajectories in community-dwellers with Alzheimer's disease.

Conclusions: Although persons with AD are often collectively considered as expensive patient group, there is large temporal and inter-individual variation in belonging to the highest decile of hospitalization and/or medication costs. It would be important to assess whether hospitalization rate could be decreased by, e.g., comprehensive outpatient care with more efficient management of comorbidities. In addition, other interventions that could decrease hospitalization rate in persons with dementia should be studied further in this context. Key messages Persons with AD had large individual fluctuation in hospital care costs and medication costs over time Hospital care costs were considerably larger than medication costs, with fractures, cardiovascular diseases and mental and behavioral disorders being the key predictors Antidementia medication was associated with lower hospital care costs. PMID: 31322423 [PubMed - as supplied by publisher]
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research

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Authors: Wanleenuwat P, Iwanowski P, Kozubski W Abstract Alzheimer's disease (AD) is the most common form of dementia manifesting as alterations in cognitive abilities, behavior and deterioration in memory which is progressive, leading to gradual worsening of symptoms. Major pathological features of AD are accumulations of neuronal amyloid plaques and neurofibrillary tangles, with early lesions appearing primarily in the hippocampus, the area of the brain involved in memory and learning. Cardiovascular related risk factors are believed to play a crucial role in disease development and the acceleration of cognitive ...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Alzheimer disease and related dementias affect nearly 10% of US adults older than 65 years. With an aging population, the prevalence of dementia is likely to increase, adding to the enormous burden on affected patients, their caregivers, and the health care system. Besides Alzheimer pathology (eg, amyloid and tau protein deposition) in the brain, there is increasing evidence of the contributions of vascular pathology (eg, stroke, subclinical infarct, and ischemic white matter changes) on dementia occurrence. Furthermore, these 2 common pathologies can coexist in individual patients, with evidence that cerebrovascular insul...
Source: JAMA - Category: General Medicine Source Type: research
Photo credit Christian Newman ...My friend can be forgiven for dragging her feet. Her mother has been told often that the brother was ill. It was new information to the mother each time. There was no reason for the daughter to think that the telling of her uncle's death was not going to shock her mother all over again. She seriously thought of not mentioning it. It's not as if a visit was expected. She asked me what I thought. Read the full article on HealthCentral to learn more about how (or if) to tell someone that their spouse or other loved one has died: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ –...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
“I can’t say when we will have a cure, but we now know through our findings how to ask the question of what is going wrong at the earliest stage of Alzheimer’s. – John O’Keefe Alzheimer’s disease is a degenerative disease of the brain that affects more than 50 million people worldwide, and 5.8 million in America alone. Dementia is its most common form. According to the Alzheimer’s Association, someone in the United States develops Alzheimer’s every 65 seconds. While there’s currently no treatment or cure that can stop Alzheimer’s or slow progression of the disease...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Alzheimer's Memory and Perception Alzheimer's disease Dementia Source Type: blogs
Authors: Lai HC, Chang QY, Hsieh CL Abstract In this article, we review signal transduction pathways through which acupuncture treats nervous system diseases. We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer's disease, dementia, vascular demen...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Background and Aims: Dementias are devastating neurodegenerative diseases with nearly 50 million people affected worldwide. There are no available curative treatments, and large parts of the underlying biology remain unknown. Clinically, Alzheimer ’s disease often coexists with cerebral vascular diseases, and the major pathological hallmark of Alzheimer’s disease is accumulation of amyloid-β in the brain and in cerebral vessels.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: E-poster session Source Type: research
Photo credit Jeremy Wong Dementia and the loss of a spouse are sad and challenging enough on their own, but when they coincide, the result can be truly heartbreaking. For many adult children, deciding whether to inform a cognitively impaired parent that their spouse has died is a serious and often recurring struggle. For someone who has not experienced such a dilemma, this would appear to be a no-brainer. However, as with many dementia-related quandaries, the question and answer are far more complex for those facing this reality. Read the full article on Agingcare to learn more about how you can try to minimize grief for y...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Photo credit Matthieu-a-b ..."Patients who appreciated music, painting and theatre recovered better from their stroke than patients who did not"Patients interested in art had better general health, found it easier to walk, and had more energy. They were also happier, less anxious or depressed, and felt calmer. They had better memory and were superior communicators (speaking with other people, understanding what people said, naming people and objects correctly)." Read the full article on HealthCentral to learn more about how music can improve life quality for people who have had a stroke or who live with deme...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Dear Candid Caregiver: My mom passed two years ago and my dad hasn’t done well since. Recently he had a stroke. My sister, who lives 1,000 miles away, came out for mom’s funeral, and she also visited for a few days after dad’s stroke, but she has a job and a family and couldn’t stay long. Now, dad’s been diagnosed with vascular dementia. Realistically, I’m the sole caregiver. Read the full article on HealthCentral for tips on how to deal with your caregiver burnout: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resource Center Support a caregiver or jump-star...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
In this study we show, for the first time, significant alterations in cholesterol efflux capacity in adolescents throughout the range of BMI, a relationship between six circulating adipocyte-derived EVs microRNAs targeting ABCA1 and cholesterol efflux capacity, and in vitro alterations of cholesterol efflux in macrophages exposed to visceral adipose tissue adipocyte-derived EVs acquired from human subjects. These results suggest that adipocyte-derived EVs, and their microRNA content, may play a critical role in the early pathological development of ASCVD. Commentary on the Developing UK Government Position on Hea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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