Positive effect of ozonotherapy on serum concentration of soluble interleukin-2 receptor and neopterin in patients with systemic sclerosis.

Conclusions: Ozonotherapy had a beneficial influence on the immune response in patients with scleroderma. Balneotherapy may be considered as an additional therapeutic option, but further research is required. PMID: 31320847 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

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Background: Systemic sclerosis (SSc) or scleroderma is a life altering and sometimes lethal, chronic autoimmune disease. SSc is characterized by excessive and persistent deposition of collagen and other extracellular matrix (ECM) molecules in the skin and internal organs, which can lead to significant and debilitating fibrosis. The Neubig Lab at Michigan State University identified a series of compounds (CCG series) that act in the Rho/MRTF/SRF pathway and attenuated collagen and smooth muscle actin expression —known fibrotic markers—in fibroblasts from SSc patients, and prevented bleomyocin-induced fibrosis in mice.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31424086 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
AbstractRaynaud ’s phenomenon (RP) is used to describe a symptom complex caused by digital vascular compromise. RP is a clinical diagnosis. The typically episodic nature of RP has resulted in a reliance upon patient self-report for diagnosis. The term ‘primary RP’ is generally applied when no underlying patho logy can be demonstrated. Whilst ‘primary RP’ is currently considered a distinct disorder, there is evidence that the term may comprise several entities that include a functional vasospastic disorder, a physiologically appropriate thermoregulatory response, subclinical atherosclerosis and...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Both Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) are autoimmune diseases sharing similar genetic backgrounds. Genome-wide association studies (GWASs) have constantly disclosed numerous genetic variants conferring to both disease risks at 7q32.1, but the functional mechanisms underlying them are still largely unknown. Through a series of bioinformatics and functional analyses, we prioritized a potential independent functional SNP (rs13239597) within TNPO3 promoter region, residing in a putative enhancer element and validated that IRF5 is the distal target gene ( ∼118kb) of rs13239597, which is a key ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
The anti-Ro52 antibody is found in a number of autoimmune diseases, including Sj ögren’s syndrome (SS), systemic lupus erythematosus, systemic sclerosis and dermatomyositis (DM)/polymyositis (PM). It is most frequently found in SS (37.4-66.7%) and second-most frequently in DM/PM (26.3-31.2%) [1]. It is also one of the most common autoantibodies in inflammatory myopathies and is classified as a myositis-associated antibody (MAA), which is frequently found in PM/DM but not specific for this diagnosis [2,3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
ConclusionAnti-DFS70 antibody was more prevalent in the subsets of SARD than BD. This result may be related to the demographic formation of study groups and individual immunological status. More comprehensive studies are needed to investigate the importance of the anti-DFS70 antibody for SARD.Key Points• This study draws attention to the importance of anti-DFS70 antibodies in the diagnostic algorithm in systemic autoimmune rheumatic diseases.• This study emphasizes the further investigation of anti-DFS70 antibodies in undifferentiated connective tissue diseases.• This study emphasizes the need to verify the ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Its pathogenesis, which is still poorly understood, features three main pathogenic moments: an initial diffuse vasculopathy followed by low-grade inflammation and a subsequent tissue fibrosis. Numerous evidences support the role of a Th2-oriented immune response during both the inflammatory and the fibrotic phase of SSc. Levels of IL-4, IL-13 and CXCL4 are higher in the serum of SSc patients compared to healthy controls. Fibrotic tissue in SSc displays a Th2 polarized CD4+ cell infiltration, influencin...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
In conclusion, the -308G>A polymorphism is a genetic marker of SSc susceptibility in population from southern Mexico, and it is associated with skin thickening and anti-fibrillarin antibodies. In addition, sTNF-α levels correlate positively with the anti-RNA pol III antibodies levels.
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Yanlin Wang, Shulan Zhang, Zhaojun Liang, Min Feng, Xiangcong Zhao, Kaili Qin, Chong Gao, Xiaofeng Li, Hui Guo, Jing LuoAbstractScleroderma is an inflammatory autoimmune disease characterized by extensive tissue fibrosis. The imbalance of effector T (Teff) and regulatory T (Treg) cells and the production of autoantibodies contribute to the pathogenesis of this disease. Metformin (MET) has anti-inflammatory and anti-fibrotic effects, but its effect on the in vivo pathogenesis of scleroderma remains unknown. Therefore, we investigated the potent...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
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