Analysis of circulating soluble programmed death 1 (PD-1), neuropilin 1 (NRP-1) and human leukocyte antigen-G (HLA-G) in psoriatic patients.
Conclusions: Increased concentrations of sNRP-1 and unchanged values of sHLA-G and sPD-1 concentrations may be indicative of impaired immune tolerance mechanisms in psoriasis. PMID: 31320849 [PubMed]
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils (PMNs) abundantly infiltrate psoriatic skin but the cues that prompt PMNs to home to the skin are not well defined. To identify PMN surface receptors that may explain PMN skin homing in psoriasis patients, we screened 332 surface antigens on primary human blood PMNs from healthy donors and psoriasis patients. We identified platelet surface antigens as a defining feature of psor...
Psoriasis severity categories have been important tools for clinicians to use in treatment decisions as well as to determine eligibility criteria for clinical studies. However, due to the heterogeneity of severity classifications and their lack of consideration for the impact of psoriasis involvement of special areas or past treatment history, patients may be mis-categorized, which can lead to under-treatment of psoriasis.
New system could flag a patient ’s learning disability to clinicians Related items fromOnMedica Too many CCGs ’ residential mental health placements are out-of-area Experts urge radical action on mental health crises Psoriasis patients need psychological care Mental and physical healthcare should be integrated CCGs ’ duties for children with disabilities
Yunlei Pan, Shunli Tang, Lina Xu, Siting Zheng, Jianjun Qiao, Hong FangIndian Journal of Dermatology, Venereology, and Leprology 2019 85(5):534-536
Soo Ick Cho, Suhwan Shin, Hanjae Lee, Seong Jin JoIndian Journal of Dermatology, Venereology, and Leprology 2019 85(5):536-538
Conclusion: The inflammatory process in psoriasis is orchestrated through chemokines. MIG is a potential serum biomarker for assessing disease severity.
Condition: Psoriasis Intervention: Device: transcutaneous electrical nerve stimulation (TENS) unit Sponsor: Wake Forest University Health Sciences Not yet recruiting
Publication date: Available online 13 August 2019Source: International Journal of PharmaceuticsAuthor(s): Mahdiyeh Bahramizadeh, Maryam Bahramizadeh, Bita Kiafar, Amir Hossein Jafarian, Amin Reza Nikpoor, Mahdi Hatamipour, Habibollah Esmaily, Zari Rezaeemehr, Shiva Golmohammadzadeh, Seyedeh Alia Moosavian, Mahmood Reza JafariAbstractThe aim of this study was to prepare and characterize topical methotrexate (MTX) with different percentages (0.05%, 0.1%, 0.25% and 0.5%) entrapped in deformable liposomes using phosphatidylcholine and oleic acid. The effectiveness and sub-acute toxicity of these topical formulations were inves...