Efficacy of ciclesonide in the treatment of patients with asthma exacerbation.

Conclusions: Treating with high doses of ciclesonide is characterised by a quick and potent anti-inflammatory effect as well as prompt clinical improvement along with the proper safety profile in patients experiencing asthma exacerbations. PMID: 31320857 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

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Mario Malerba1,2*, Valentina Foci1,2, Filippo Patrucco1,2, Patrizia Pochetti1,2, Matteo Nardin3, Corrado Pelaia4 and Alessandro Radaeli5 1Respiratory Medicine, Department of Translational Medicine, University of Eastern Piedmont, Vercelli, Italy 2Respiratory Unit, Sant’Andrea Hospital, Vercelli, Italy 3Department of Medicine, Spedali Civili di Brescia, Brescia, Italy 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia” of Catanzaro, Catanzaro, Italy 5Department of Emergency, Spedali Civili di Brescia, Brescia, Italy Chronic obstructiv...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: The cold-sensitive asthmatic patients experience frequent recurrent and/or aggravated symptoms and have obvious lung function impairment. Different from that in patients with classic asthma, the airway inflammatory phenotype in these patients is characterized by the domination by neutrophilic subtype. PMID: 30890506 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
A 42-year-old male patient was referred to hospital with symptoms of shortness of breath, wheezing and dry cough. The patient complains have begun four months ago. Due to them he was diagnosed previously with asthma, and treatment with fixed combination of inhaled corticosteroid and long-acting beta2 agonists was started, but without effect. Laboratory data and chest X-ray conducted in the hospital were normal. The spirometry showed normal FVC, FEV1 and significant reduction of PEF. The flow/volume loop was typically flattened during inspiration and expiration. It was the reason for decision that there is tracheal obstruct...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Asthma control could be maintained in more than 55% of WCA patients after step down. Regarding potential long term steroid inhaler adverse effects, steroid dose reduction with montelukast continuation could be tried in WCA patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Conclusion: Treatment with mepolizumab is associated with an attenuated symptom response to prednisolone treatment in severe eosinophilic asthma via a mechanism that is likely to be independent of changes in airflow limitation.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway Pharmacology and Treatment Source Type: research
Mepolizumab reduces exacerbations of SEA. The nature of exacerbations on mepolizumab is unclear. We have tested the hypothesis that these exacerbations differ in inflammatory profile, symptoms, FEV1 and response to oral corticosteroids (OCS).Methods: A RCT of mepolizumab in SEA was conducted (Haldar, NEJM 2009;360). Subjects were reviewed at exacerbation, prior to starting treatment or as soon as possible after. Spirometry, Asthma Control Questionnaire (ACQ5), visual analogue scale (VAS) (cough, breathlessness, wheeze) and induced sputum counts were measured.Results: 177 exacerbations were assessed-101 prior to treatment (...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway Pharmacology and Treatment Source Type: research
Conclusion: ABPA is commonly misdiagnosed as pulmonary TB in high burden TB country. Early diagnosis and appropriate treatment can prevent the structural damage to the lungs.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusions: Among children with asthma and chronic exposure to woodsmoke, an air-filter intervention that improved indoor air quality did not affect quality-of-life measures. Intent-to-treat analysis did show an improvement in the secondary measure of dPFV. Trial registration: ClincialTrials.gov NCT00807183. https://doi.org/10.1289/EHP849 Received: 21 July 2016 Revised: 13 June 2017 Accepted: 16 June 2017 Published: 13 September 2017 Address correspondence to C.W. Noonan, School of Public and Community Health Sciences, 32 Campus Dr., University of Montana, Missoula, MT 59812 USA. Telephone: (406) 243-4957; Fax: (406...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
(Reuters Health) ― As many as one in three adults diagnosed with asthma may not actually have the chronic lung disorder, a Canadian study suggests. Researchers did lung function tests on 613 adults who had been diagnosed with asthma within the past five years. If participants took asthma medicines, researchers gradually weaned them off the drugs over four clinic visits to see how well their lungs worked without treatment. The evaluations ruled out asthma in 203 of the participants, or 33 percent. After one year of follow-up, 181 of these people still did too well on lung tests to be diagnosed with asthma, researchers rep...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Introduction: Bronchiectasis may contribute to severe asthma.Aim: To estimate the presence of bronchiectasis in severe asthma and the relation with the clinical and functional parameters.Methods: We included patients with severe uncontrolled asthma.Symptoms, number of exacerbations/year, courses of corticosteroids and antibiotics/year, spirometry, and bronchial colonization were estimated. The Smith scale for bronchiectasis was estimated by HRCT (score 0-24), taking a score≥3 as radiologically significant.Results: Forty patients were studied, 28 women, mean age 57.9 years, 32 non smokers. Mean ACT score was 14.2.The mai...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 10.1 Respiratory Infections Source Type: research
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