Genotype 1 and 3 response to Velpatasvir and Sofosbuvir in Chronic Hepatitis C in Kashmiri population: An observational study

Publication date: Available online 19 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Suresh Gorka, Ghulam Mohd Gulzar, Ghulam Nabi Yattoo, Jaswinder Singh Sodhi, Gulzar Ahmad Dar, Mushtaq Ahmad Laway, Saurabh Kaushik, Neeraj Dhar, Syed Mushfiq, Riffat Abdul AzizAbstractBackground/ObjectiveOur data is one of the earliest study from Indian subcontinent on Velpatasvir/Sofosbuvir (VEL/SOF) combination in chronic hepatitis C (CHC). The primary end point was to evaluate the sustained virologic response (SVR-12) in CHC infected patients and to determine its effect in patients with HCV related cirrhosis. The secondary end point was to observe any adverse events related to treatment.MethodsAll patients of chronic hepatitis C (CHC) were randomized into two groups: Non-cirrhotic and Cirrhotic. The combination of VEL/SOF was given as recommended.ResultsHundred patients with CHC infection treated with VEL/SOF regimen were evaluated. 79 (79%) out of 100 patients were non-cirrhotic and 21 (21%) were cirrhotic. We achieved SVR-12 in 99 (99%) out of 100 patients. Among cirrhotics, the mean serum bilirubin (mg/dl), albumin (g/dl) and platelets count (x10³/μL) improved from baseline 1.82 ± 0.87, 3.22 ± 0.69 and 80.19 ± 46.03 to 1.74 ± 0.87, 3.48 ± 0.72 and 85.05 ± 42.50 respectively at SVR-12 (P-value> 0.05). Mean serum ALT (U/L) improved from baseline 71.28 ± 59.17 to 35.38 ± 17.39 at SVR-12 (P-value
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research

Related Links:

Publication date: Available online 19 July 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Suresh Gorka, Ghulam M. Gulzar, Ghulam N. Yattoo, Jaswinder S. Sodhi, Gulzar A. Dar, Mushtaq A. Laway, Saurabh Kaushik, Neeraj Dhar, Syed Mushfiq, Riffat A. AzizBackgroundOur data is one of the earliest study from the Indian subcontinent on Velpatasvir/Sofosbuvir (VEL/SOF) combination in chronic hepatitis C (CHC). The primary end point was to evaluate sustained virologic response (SVR) 12 in CHC-infected patients and to determine its effect in patients with hepatitis C virus–related cirrhosis. The sec...
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
ConclusionIn chronic HCV, progressive decline in platelets and growth factors with fibrosis and their associations suggest that platelets are an important source of circulating GFs and influence GF decline with fibrosis. Enhanced markers of vascular injury in patients with early fibrosis suggest an earlier onset of endothelial dysfunction preceding cirrhosis. Associations of VIMs with platelets suggest a critical link between platelets and vascular homeostasis. Circulating markers of vascular injury may not only have prognostic importance but emphasize the role of vascular dysfunction in liver disease pathogenesis (NCT00001971).
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Abstract The human microbiota is a variety of different microorganisms. The composition of microbiota varies from host to host, and it changes during the lifetime. It is known that microbiome may be changed because of a diet, bacteriophages and different processes for example, such as inflammation. Like all other areas of medicine, there is a continuous growth in the area of microbiology. Different microbes can reside in all sites of a human body, even in locations that were previously considered as sterile; for example, liver, pancreas, brain and adipose tissue. Presently one of the etiological factors for liver ...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Publication date: Available online 8 August 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Srikanta Dash, Yucel Aydin, Tong WuAbstractThe molecular mechanism(s) how liver damage during the chronic hepatitis C virus (HCV) infection evolve into cirrhosis and hepatocellular carcinoma (HCC) is unclear. HCV infects hepatocyte, the major cell types in the liver. During infection, large amounts of viral proteins and RNA replication intermediates accumulate in the endoplasmic reticulum (ER) of the infected hepatocyte, which creates a substantial amount of stress response. Infected hepatocyte activates a differen...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
Abstract Hepatocellular carcinoma (HCC) is a common and deadly malignancy. The disease usually develops on a background of chronic liver disease. Until recently, the most common etiology was infection with the hepatitis C virus (HCV). The advent of direct-acting antiviral (DAA) therapies has been a major breakthrough in HCV treatment. Sustained virologic response can now be achieved in almost all treated patients, even in patients with a high risk for the development of HCC, such as the elderly or those with significant fibrosis. Early reports raised concerns of a high risk for HCC occurrence after DAA therapy bot...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Conclusions: PPI use was associated with significant alterations in the microbial community in patients with chronic hepatitis C, which were even pronounced in patients with liver cirrhosis. In patients with decompensated liver cirrhosis due to chronic HCV infection, the use of PPI may promote infections either directly or indirectly through changes in the microbial community structure. Future studies should further investigate long-term impact on the microbiota and the clinical outcome. PMID: 31361979 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Abstract OBJECTIVES: Chronic hepatitis C virus (HCV) infection is typically asymptomatic until severe liver disease occurs and even then can remain undiagnosed for some time; thus, screening and treatment of asymptomatic persons are needed to prevent poor outcomes. In a previous analysis of data from between 2006 and 2011, we found that 17% of newly diagnosed HCV infections in 4 large health systems were among persons with cirrhosis and/or end-stage liver disease, termed "late diagnosis." We sought to determine the proportion with late diagnosis during 2014-2016, after release of CDC baby boomer (1945-19...
Source: The American Journal of Managed Care - Category: Health Management Authors: Tags: Am J Manag Care Source Type: research
This is so far the first meta ‐analysis about TM6SF2 polymorphisms and chronic liver disease. Our pooled analyses suggested that rs58542926 polymorphism was significantly associated with chronic liver disease in both Asians and Caucasians. Future investigations are warranted to explore potential roles of other TM6SF2 polymorph isms in the development of chronic liver disease. AbstractBackgroundSome genetic association studies tried to investigate potential associations of transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms with chronic liver disease. However, the results of these studies were not consistent. Thus...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Chronic hepatitis C (HCV) patients commonly have insulin resistance which is a risk factor for disease progression. Oesophageal varices may bleed with high mortality. We aimed to assess the relationship between insulin resistance and oesophageal varices. HCV-related compensated liver cirrhosis patients (n = 146) underwent gastroscopy and homeostasis model assessment (HOMA)-IR, HOMA-β and HOMA-S calculations. Their average age was 54.98 years; most (84.9%) patients were men and non-diabetic (60.3%). Patients with oesophageal varices had higher median Model for End-Stage Liver Disease (ME...
Source: Tropical Doctor - Category: Tropical Medicine Authors: Tags: Trop Doct Source Type: research
Conclusion In patients with chronic hepatitis C genotype 3, SOF/RBV and SOF/DCV±RBV have similar sustained viral response, and patients with liver cirrhosis and past treatment experience have suboptimal response in Pakistan.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
More News: Bilirubin | Children | Cirrhosis | Gastroenterology | Hepatitis | Hepatitis C | India Health | Legislation | Liver | Liver Disease | Study | Urology & Nephrology | Virology