A mixed two-dose vaccination schedule: Not enough evidence to support a policy change in Quebec.

A mixed two-dose vaccination schedule: Not enough evidence to support a policy change in Quebec. Vaccine. 2019 Jul 26;37(32):4421 Authors: Rosberger Z, Steben M, Norris T, McFadyen A, Shapiro GK PMID: 31319930 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Conclusion: The perception of health risk of contracting influenza and a primary healthcare physicians' recommendation played an important role in shaping participants' decisions towards vaccination. Primary healthcare physicians are invited to assess and if necessary adjust inappropriate prevention behaviour through their everyday patient consultations as well as add to the knowledge about influenza severity and influenza vaccination benefits to their patients. PMID: 31431093 [PubMed - as supplied by publisher]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
Publication date: Available online 23 August 2019Source: Nano TodayAuthor(s): Rein Verbeke, Ine Lentacker, Stefaan C. De Smedt, Heleen DewitteAbstractIn the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool for vaccination. In the following decades, an improved understanding of the mRNA pharmacology, together with novel insights in immunology have positioned mRNA-based technologies as next-generation vaccines. This review outlines the history and current state-of-the-art in mRNA vaccination, while presenting an immunological view on mRNA vaccine development. As such, we highlight the chal...
Source: Nano Today - Category: Nanotechnology Source Type: research
This study examined the effect of NH3 on the immune response to infectious bronchitis virus (IBV) vaccination and protection against homologous serotype challenge in commercial broiler chickens. One-day-old chicks were administered IBV vaccine and exposed to 30-60 ppm of NH3. At 28 DOA, birds were challenged oculonasally with a pathogenic homologous IBV, and protection was measured by viral detection, clinical signs, ciliostasis, and presence of airsacculitis. IBV-specific serum IgG and lacrimal fluid IgA titers, as well as Harderian gland (HG) immune cell phenotypes, were evaluated. Ammonia exposure was associated ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Source: American Journal of Health Behavior - Category: Psychiatry & Psychology Authors: Source Type: research
Publication date: Available online 23 August 2019Source: Microbial PathogenesisAuthor(s): Lulu Chen, Jialong Zhang, Minmin Wang, Shuonan Pan, Chunxiao Mou, Zhenhai ChenAbstractSeneca Valley virus (SVV) has been identified as the causative agent of SVV-associated vesicular disease (SAVD). To investigate the pathogenicity of two newly isolated SVV strains (GD-S5/2018 and GD04/2017) in China, experimental infections of mice and pigs were performed. SVV GD-S5/2018 was lethal to mice infected by intramuscular, intraperitoneal, or oral routes, while SVV GD04/2017 was avirulent without causing any discernible clinical signs in mi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: 22 August 2019Source: Cell, Volume 178, Issue 5Author(s): Maria Carolina Amezcua Vesely, Paris Pallis, Piotr Bielecki, Jun Siong Low, Jun Zhao, Christian C.D. Harman, Lina Kroehling, Ruaidhrí Jackson, Will Bailis, Paula Licona-Limón, Hao Xu, Norifumi Iijima, Padmini S. Pillai, Daniel H. Kaplan, Casey T. Weaver, Yuval Kluger, Monika S. Kowalczyk, Akiko Iwasaki, Joao P. Pereira, Enric EspluguesSummaryAdaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (TRM) cells. However, the cellu...
Source: Cell - Category: Cytology Source Type: research
We describe reference materials that have been or are being developed for haemorrhagic fever viruses and consider the issues surrounding their production, particularly that of biosafety where the viruses require specialised containment facilities. Finally, we advocate the use of reference materials at early stages, including research and development, as this helps produce reliable assays and can smooth the path to regulatory approval.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
a Cupic Hepatitis B virus (HBV) reactivation occurs as a major complication of immunosuppressive therapy among persons who have recovered from acute hepatitis and those who have controlled chronic infection. Recent literature data emphasize the presence of a high degree of S gene variability in HBV isolates from patients who developed reactivation. In reactivated HBV, the most frequently detected mutations belong to the second loop of “a” determinant in HBsAg. These mutations were identified to be immune escape and responsible for vaccine- and diagnostic-escape phenomena. Their emergence clearly pro...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
AbstractBackgroundInfluenza is an acute viral respiratory illness that causes high morbidity and mortality globally. Therapeutic actions are limited to vaccines and a few anti-viral drugs.Polygala(P.) japonica herba is rich in Polygalasaponin F (PSF, C53H86O23), used for acute bronchitis, pharyngitis, pneumonia, amygdalitis, and respiratory tract infections treatment in China. Hypercytokinemia is often correlated with severe pneumonia caused by several influenza viruses. PSF was reported to have anti-inflammatory effects and its mechanism is associated with the nuclear factor (NF)- κB signaling pathway. The action of...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbre...
Source: Advances in Virus Research - Category: Virology Source Type: research
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