Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes.

Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes. Stress. 2019 Jul 19;:1-12 Authors: Tseilikman V, Dremencov E, Tseilikman O, Pavlovicova M, Lacinova L, Jezova D Abstract Glucocorticoid signaling is fundamental in healthy stress coping and in the pathophysiology of stress-related diseases, such as post-traumatic stress disorder (PTSD). Glucocorticoids are metabolized by cytochrome P450 (CYP) as well as 11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and 2 (11βHSD2). Acute stress-induced increase in glucocorticoid concentrations stimulates the expression of several CYP sub-types. CYP is primarily responsible for glucocorticoid metabolism and its increased activity can result in decreased circulating glucocorticoids in response to repeated stress stimuli. In addition, repeated stress-induced glucocorticoid release can promote 11βHSD1 activation and 11βHSD2 inhibition, and the 11βHSD2 suppression can lead to apparent mineralocorticoid excess. The activation of CYP and 11βHSD1 and the suppression of 11βHSD2 may at least partly contribute to development of the blunted glucocorticoid response to stressors characteristic in high trait anxiety, PTSD, and other stress-related disorders. Glucocorticoids and glucocorticoid-metabolizing enzymes interact closely with other biomolecules such as inflammatory cytokines, monoamines, and some monoamine-metabolizing enzymes, ...
Source: Stress - Category: Research Tags: Stress Source Type: research

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Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
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Source: Journal of Anxiety Disorders - Category: Psychiatry Source Type: research
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Source: Neurobiology of Stress - Category: Neuroscience Source Type: research
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Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: Neuroscience - Category: Neuroscience Source Type: research
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