The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

ORMDL3 regulates systemic ceramide levels, but genetically interfering with Ormdl3 expression does not result in altered experimental asthma.

Source: Journal of Allergy and Clinical Immunology - July 19, 2019 Category: Allergy & Immunology Authors: Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht Source Type: research