Evaluation of the STAT3 inhibitor GLG ‑302 for the prevention of estrogen receptor‑positive and ‑negative mammary cancers.

Evaluation of the STAT3 inhibitor GLG‑302 for the prevention of estrogen receptor‑positive and ‑negative mammary cancers. Oncol Rep. 2019 Jul 04;: Authors: Shoemaker RH, Fox JT, Juliana MM, Moeinpour FL, Grubbs CJ Abstract Signal transducer and activator of transcription 3 (STAT3) plays a key role in the transformation of normal cells to cancerous cells. Although inhibitors of STAT3 have been shown to suppress the growth of multiple cancer types in vitro and in vivo, such agents are of particular interest for the prevention of breast cancer, which affects over 200,000 women and claims more than 40,000 lives in the United States each year. In the present study, we employed the MMTV/Neu transgenic mouse model, which develops estrogen receptor (ER)‑negative, Neu‑overexpressing tumors, and the Sprague‑Dawley (SD) rat model, which develops ER‑positive tumors upon exposure to the carcinogen 7,12‑dimethylbenz[a]anthracene (DMBA), to test the efficacy of the STAT3 inhibitor GLG‑302 in the prevention of mammary cancer. Orally administered GLG‑302 and its trizma salt derivative reduced mammary cancer incidence, multiplicity, and tumor weights in female MMTV/Neu mice, and GLG‑302 reduced tumor multiplicity and weights in female DMBA‑treated rats. Consistent with the mechanism of action of STAT3 inhibitors, the reductions in mammary tumors were correlated with decreases in STAT3 phosphorylation and cell proli...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Source: Radiologia Brasileira - Category: Radiology Source Type: research
Conclusion: Breast MRI is an useful tool for the locoregional staging of breast cancer, because it provides useful information that can have a positive impact on patient treatment.Resumo Objetivo: Avaliar o impacto do uso da resson ância magnética (RM) no estadiamento pré-operatório do câncer de mama. Materiais e Métodos: Foram avaliadas 61 pacientes com carcinoma mamário submetidas a RM das mamas, no período de agosto de 2015 a abril de 2016. Um mastologista foi questionado sobre a conduta terapêutica indicada diant e dos dados da paciente e dos exames convencion...
Source: Radiologia Brasileira - Category: Radiology Source Type: research
ConclusionTogether these results emphasize an anti-tumorigenic role with a potential therapeutic value for PRL in HER-2 and luminal B breast cancer subtypes targeting the cancer stem-like cells.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Condition:   Breast Cancer Interventions:   Drug: Ipatasertib;   Drug: Placebo;   Drug: Palbociclib;   Drug: Fulvestrant Sponsor:   Hoffmann-La Roche Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Breast Cancer Intervention:   Other: Observational study Sponsor:   CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Brain Metastases Intervention:   Radiation: Fractionated stereotactic radiotherapy(FSRT) Sponsor:   Fudan University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Todd W Miller ; Sarah R HosfordSeries Type : SNP genotyping by SNP array ; Genome variation profiling by SNP arrayOrganism : Homo sapiensEstrogens have been shown to elicit anti-cancer effects against estrogen receptor alpha (ER)-positive breast cancer. We sought to determine the underlying mechanism of therapeutic response. Response to 17b-estradiol was assessed in ER+ breast cancer models with resistance to estrogen deprivation: WHIM16 patient-derived xenografts, C7-2-HI and C4-HI murine mammary adenocarcinomas, and long-term estrogen-deprived MCF-7 cells. As another means to reactivate ER, the anti-estrog...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: SNP genotyping by SNP array Genome variation profiling by SNP array Homo sapiens Source Type: research
Contributors : Todd W Miller ; Sarah R HosfordSeries Type : Expression profiling by arrayOrganism : Homo sapiensEstrogens have been shown to elicit anti-cancer effects against estrogen receptor alpha (ER)-positive breast cancer. We sought to determine the underlying mechanism of therapeutic response. Response to 17b-estradiol was assessed in ER+ breast cancer models with resistance to estrogen deprivation: WHIM16 patient-derived xenografts, C7-2-HI and C4-HI murine mammary adenocarcinomas, and long-term estrogen-deprived MCF-7 cells. As another means to reactivate ER, the anti-estrogen fulvestrant was withdrawn from fulves...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Mohamed M. Fathy, Heba M. Fahmy, Omnia A. Saad, Wael M. ElshemeyAbstractAimsConventional radiotherapy is mainly restricted by the low radiation absorption efficiency of tumors tissues and the hypoxic tumor cells radio-resistance. In this paper, novel nano-radiosensitizers, magnetic nanoparticles core coated with silica, were successfully prepared to overcome these limitations.Main methodsThe prepared nanoparticles have been characterized by transmission electron microscope (TEM), Dynamic light scattering (DLS), atomic force microscope (AFM) and vib...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Photochemistry and Photobiology A: ChemistryAuthor(s): M. Waseem Akram, Fazal Raziq, Muhammad Fakhar-e-Alam, Muhammad Hammad Aziz, K.S. Alimgeer, M. Atif, M. Amir, Atif Hanif, W. Aslam FarooqAbstractAu-TiO2 nanoparticles conjugated with doxorubicin (DOX) were synthesized for new photodynamic therapy (PDT) plans and for comprehensive and reliable treatment of breast cancer-related acute diseases. The anatase/rutile phase junction effect combined with plasmonic resonance is amplified in Au- TiO2 conjugated with DOX, leading to a synergistic response of PDT. ...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
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