Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease.

Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease. Oncotarget. 2019 Jul 08;10(43):4492-4500 Authors: Maiuri L, Raia V, Piacentini M, Tosco A, Villella VR, Kroemer G Abstract Cystic Fibrosis (CF) is the most frequent lethal monogenetic disease affecting humans. CF is characterized by mutations in cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel whose malfunction triggers the activation of transglutaminase-2 (TGM2), as well as the inactivation of the Beclin-1 (BECN1) complex resulting in disabled autophagy. CFTR inhibition, TGM2 activation and BECN1 sequestration engage in an 'infernal trio' that locks the cell in a pro-inflammatory state through anti-homeostatic feedforward loops. Thus, stimulation of CFTR function, TGM2 inhibition and autophagy stimulation can be used to treat CF patients. Several studies indicate that patients with CF have a higher incidence of celiac disease (CD) and that mice bearing genetically determined CFTR defects are particularly sensitive to the enteropathogenic effects of the orally supplied gliadin (a gluten-derived protein). A gluten/gliadin-derived peptide (P31-43) inhibits CFTR in mouse intestinal epithelial cells, causing a local stress response that contributes to the immunopathology of CD. In particular, P31-43-induced CFTR inhibition elicits an epithelial stress response perturb...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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Peripheral artery disease (PAD) has been shown to affect health status and quality of life; however, the disability associated by specific anatomic level of disease is unknown. We evaluated patients presenting with claudication by anatomic level and used the Peripheral Artery Questionnaire (PAQ), a validated tool for PAD, to quantify patients' symptoms, function, treatment satisfaction, and quality of life.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2019 Midwestern Vascular Surgical Society Annual Meeting Source Type: research
CONCLUSIONS: We confirm that homeless people often suffer from cognitive difficulties, and some of these difficulties (memory, executive functioning) are severe. Yet the etiology of these disorders remain relatively unknown: even if we observe a high prevalence of psychiatric, substance-related, neurodevelopmental and neurological issues by the homeless population, only a few of them (brain injury history and childhood trauma) seem to be correlated with cognition in homelessness. The potential explicative factors have been too rarely explored to bring a powerful explanation of cognitive disorders in homeless people. Furthe...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Authors: Kalogerakis Z, Petroutsou A, Chatzakis A, Ploumpidis D, Papageorgiou C, Economou M Abstract Psychosocial rehabilitation for people with chronic-severe mental illness mainly aims to social integration by restoring independent functioning in the community, improving quality of life, and addressing risk factors that lead to social disability. Support groups (SG) are usually part of this multilevel mental health process. Given that non-adherence to treatment is a common phenomenon in people with chronic- severe mental illness, the aim of the current study was to identify which factors influence members' attend...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Background: Chronic wounds, including diabetic ulcers, venous ulcers, and pressure ulcers, are characterized by physiological impairments manifested by delayed healing, leading in some cases to permanent disability and increased morbidity. Delay in wound healing is multifactorial; it can be attributed to excessive inflammation, fibroblast senescence, alterations in wound bed flora, and other exposures. Herein we sought to evaluate clinicopathological characteristics that contribute to prolonged healing times in chronic nonhealing wounds.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Phototherapy is a treatment prescribed in different dermatological conditions, mainly in which topical treatments are insufficient due to extension, localization, severity, disability or affection in quality of life. However, it is rarely used in the pediatric age in our environment, possibly due to the lack of knowledge and/or training by dermatologists and the fear of possible adverse effects. We wanted to identify the type of phototherapy implemented in children and keep records of our own statistics.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the folliculopilosebaceous units. It is characterized by recurrent inflammatory nodules that may progress to draining sinuses with scar formation. HS often results in severe pain, disability, and disfigurement. It appears that genes play a role in HS, with an estimated 40% of patients having an affected first-degree family member. Research on a few families documents an autosomal dominant pattern of inheritance, but HS remains poorly understood without any large-scale genetic evaluations to date.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
CONCLUSIONS The results of this study indicate that PRP elicits higher healing activity in the first 7 days postlesion. Treatments with RSV alone or RSV and PRP did enhance other healing phases.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: ONLINE EXCLUSIVE Source Type: research
The purpose of this study is to appraise Global Burden of Disease (GBD) and PatientsLikeMe.com (PLM) databases for the evaluation of dermatologic disease. Utilizing the GBD results tool [http://ghdx.healthdata.org/gbd-results-tool], incidence and prevalence data was extracted. In PLM, total number of subscribers for each disease and male/female distribution were assessed. Diseases analyzed were of the top fourteen diseases with the highest disability-adjusted life-year. As of September 2018, there were 658,183 total members on PLM and 7.1x109 total diagnoses reported by the GBD.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
Condition:   Hearing Disability Interventions:   Behavioral: Audiological rehabilitation;   Behavioral: Placebo Rehabilitation Sponsors:   Universitaire Ziekenhuizen Leuven;   KU Leuven Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: This study indicates an increasing burden of IA in Iran, despite the extensive use of prophylaxis, challenging the public health, especially immunocompromised patients. PMID: 31426666 [PubMed - as supplied by publisher]
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
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