DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy.

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy. J Oncol. 2019;2019:4325105 Authors: Gilmore E, McCabe N, Kennedy RD, Parkes EE Abstract Historically the development of anticancer treatments has been focused on their effect on tumor cells alone. However, newer treatments have shifted attention to targets on immune cells, resulting in dramatic responses. The effect of DNA repair deficiency on the microenvironment remains an area of key interest. Moreover, established therapies such as DNA damaging treatments such as chemotherapy and PARP inhibitors further modify the tumor microenvironment. Here we describe DNA repair pathways in breast cancer and activation of innate immune pathways in DNA repair deficiency, in particular, the STING (STimulator of INterferon Genes) pathway. Breast tumors with DNA repair deficiency are associated with upregulation of immune checkpoints including PD-L1 (Programmed Death Ligand-1) and may represent a target population for single agent or combination immunotherapy treatment. PMID: 31320901 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research

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Authors: Gaston J, Cheradame L, Yvonnet V, Deas O, Poupon MF, Judde JG, Cairo S, Goffin V Abstract [This corrects the article DOI: 10.18632/oncotarget.12858.]. PMID: 31289622 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Inspiration & Hope Mental Health and Wellness Motivation and Inspiration Personal Self-Help Stigma Depression Support Depressive Episode Personal Growth Sleep stress reduction Source Type: blogs
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Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
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Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: allergens annoyance reactions Source Type: blogs
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Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
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