Protective effect of ISO ‑1 against advanced glycation end product aggravation of PC12 cell injury induced by Aβ1‑40.

Protective effect of ISO‑1 against advanced glycation end product aggravation of PC12 cell injury induced by Aβ1‑40. Mol Med Rep. 2019 Jul 09;: Authors: Yu M, Zang D, Xu Y, Meng J, Qian S Abstract Advanced glycation end products (AGEs) are important pathogenic substances involved in diabetes mellitus (DM) and its complications. AGEs also serve important roles in promoting the development of Alzheimer's disease (AD). Macrophage migration inhibitory factor (MIF), an inflammatory stimulant and a pathogenic factor involved in DM, was previously reported to be present at increased levels in the cerebrospinal fluid of patients with AD and mild cognitive impairment compared with age‑matched healthy controls. By investigating the association between AGEs and MIF, and the effects of neuroinflammation on AD, the present study aimed to increase understanding of the specific molecular mechanisms involved in the pathogenesis of DM and AD, and the connection between these diseases. PC12 cells were cultured in vitro; the levels of MIF mRNA and protein were determined using reverse transcription‑quantitative (RT‑q)PCR and western blot analyses. The optimal concentrations of AGEs and amyloid β 1‑40 (Aβ1‑40) were also determined in the cell model of AD using Cell Counting Kit‑8 and MTT assays. Cell numbers and morphological changes were observed following the treatment of Aβ1‑40‑stimulated PC12 cells with AGEs and...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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CONCLUSIONS: Diabetes, even prediabetes and changes of diabetes-related biochemical indicators, predicted increased incidence of cognitive impairment and dementia. The protective effects of pioglitazone warrant further investigation in randomized trials. PMID: 31430566 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
ConclusionThis study rendered a preliminary overview of anti-cholinesterase activity from diverse Malaysian botanical families in which provided the medical relevance toward these native plant species, especially ones with limited ethnobotanical record or practice.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe relationships between DM and AD identified by PET appear to be independent of amyloid deposition and predominantly highlighted by reduced glucose metabolism, as suggested by four of the five glucose metabolism studies.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Nandini H S, Yam Nath Paudel, Krishna K LAbstractEpilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1% of global population making it a serious health concern. Despite the recent advances in epilepsy research, no disease-modifying treatment able to terminate epileptogenesis have been reported yet reflecting the complexity in understanding the disease pathogenesis. To overcome the current treatment gap against epilepsy, one effective approach is to explore ...
Source: Life Sciences - Category: Biology Source Type: research
I read the AFPI position paper on road safety and public health with interest.[1] The authors mentioned the use of alcohol, co-morbid medical conditions (diabetes mellitus, Parkinson's disease, Alzheimer's disease, epilepsy), and adverse drug reactions ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Abstract Aggregates formed by amylin (a neuroendocrine peptide hormone secreted by pancreatic β-cells) are implicated in the pathogenesis of type 2 diabetes mellitus. To understand amylin's aggregation mechanism and discover its inhibitory drugs, we have reviewed experimental and computational studies on amylin structures and inhibitors. We have also reviewed the role of amylin in other conditions including obesity and Alzheimer's disease (AD), since effective therapeutics are still lacking for AD. Our results of text-mining over 3,000 amylin-related PubMed abstracts suggest the combined therapeutic potential...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
DIABETES DRUGS IN THE FIGHT AGAINST ALZHEIMER'S DISEASE. Ageing Res Rev. 2019 Jul 19;:100936 Authors: Boccardi V, Murasecco I, Mecocci P Abstract Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age subjects. Hyperinsulinemia and insulin resistance, which are known as pathophysiological features of Type 2 Diabetes Mellitus (T2DM), have also been demonstrated to have a significant impact on cognitive impairment. Studies have shown that an altered insulin pathway may interact with amyloid-β protein deposition and tau protein phosphorylation, both leading factors ...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
Conclusions: Overall, Periventricular WMHs of grade 2 and over were seen in 19/34 patients, and in 7/24 controls (P value 0.044). Significantly higher grades of PVWMHs were seen in hypertensives as compared to nonhypertensives in the case group, and in women compared to men. In the control group, hypertension had no effect on severity of PVWMHs. Among both Diabetics and non-diabetics, no difference in PVWMHs was found between the case and control groups. DWMHs were, conversely, seen only in the control group. Overall, over a quarter of cognitively normal older persons had WM hyperintensities of grade 2 and over on MRI brai...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Publication date: Available online 9 July 2019Source: Neurochemistry InternationalAuthor(s): Tong Ren, Jinfeng Liu, Yunlong Ge, Rengong Zhuo, Lu Peng, Feng Liu, Xin Jin, Lichao YangAbstractBrain is a site of diabetic end-organ damage. Diabetes-associated cognitive dysfunction, referred as “diabetic encephalopathy” (DE) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. Current evidence supported that aberrant synapses, energy meta...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Neutrophil extracellular traps (NETs) are web-like extrusions of genetic material, which are released upon neutrophil activation. NETs consist of a chromatin substructure, onto which a vast array of proteins with various properties is dispersed. NETs production was initially described as an unrecognized defense mechanism of neutrophils, due to their ability to entrap and possibly eliminate a wide range of pathogens. Nevertheless, growing evidence suggests that NETs are implicated in a multitude of pathophysiological conditions, such as autoimmunity, cancer, diabetes mellitus and Alzheimer's disease.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Review article Source Type: research
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