The tripartite mechanism as the basis for a biochemical memory engram.

The tripartite mechanism as the basis for a biochemical memory engram. J Integr Neurosci. 2019 Jun 30;18(2):181-185 Authors: Marx G, Gilon C Abstract In this paper, we address the enigma of the memory engram, the physical trace of memory in terms of its composition, processes, and location. A neurochemical approach assumes that neural processes hinge on the same terms used to describe the biochemical functioning of other biological tissues and organs. We define a biochemical process, a tripartite mechanism involving the interactions of neurons with their neural extracellular matrix, trace metals, and neurotransmitters as the basis of a biochemical memory engram. The latter inextricably link physiological responses, including sensations with affective states, such as emotions. PMID: 31321959 [PubMed - in process]
Source: Journal of Integrative Neuroscience - Category: Neuroscience Authors: Tags: J Integr Neurosci Source Type: research