Physicists Probe Stress-Induced Changes In Clot-Forming Protein

New research from Rice University, Baylor College of Medicine (BCM) and the Puget Sound Blood Center (PSBC) has revealed how stresses of flow in the small blood vessels of the heart and brain could cause a common protein to change shape and form dangerous blood clots. The scientists were surprised to find that the proteins could remain in the dangerous, clot-initiating shape for up to five hours before returning to their normal, healthy shape. The study -- the first of its kind -- focused on a protein called von Willebrand factor, or VWF, a key player in clot formation...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Blood / Hematology Source Type: news

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In conclusion, the development of VWF-specific mAbs would be useful in the diagnosis of VWD and AVWS. PMID: 31192778 [PubMed - in process]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Source: Blood - Category: Hematology Authors: Tags: Free Research Articles COMMENTS Source Type: research
During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiogenesis and promote wound healing through GF binding. The hemostatic protein von Willebrand factor (VWF) released by endothelial cells (ECs) in plasma and in the subendothelial matrix has been shown to regulate angiogenesis; this function is relevant to patients in whom VWF deficiency or dysfunction is associated with vascular malformations. Here, we show that VWF deficien...
Source: Blood - Category: Hematology Authors: Tags: Plenary Papers, Thrombosis and Hemostasis, Vascular Biology Source Type: research
Von Willebrand Disease is a common cause of excessive bruising and bleeding in children. This short article gives advice on diagnosis and management for paediatricians. Given its prevalence and presenting symptoms, VWD should always be considered in the assessment of children suspected of non-accidental injury. Its diagnosis can be challenging, not only because of the various subtypes of the disorder but because of the considerable overlap between VWD and normal individuals. Laboratory diagnosis requires a range of quantitative and qualitative tests of the VWF protein, with targeted gene analysis increasingly used to confi...
Source: Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Symposium: haematology Source Type: research
Abstract Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel disease (SVD). However, the underlying mechanisms and causative pathways remain unclear. We systematically reviewed the existing literature on the associations between markers of inflammation and SVD (i.e., white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces (EPVS), cerebral microbleeds (CMB)) in cohorts of older people with good health, cerebrovascular disease, or cognitive impairment. Based on distinctions made in the literature, markers of inflammation were classified as systemic infla...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
Authors: Formes H, Reinhardt C Abstract INTRODUCTION: There is emerging evidence linking the commensal gut microbiota with the development of cardiovascular disease and arterial thrombosis. In immunothrombosis, the host clotting system protects against the dissemination of invading microbes, not considering the huge number of microbes that interact with host physiology in a mutualistic fashion. Areas covered: Interestingly, recent research revealed that colonizing gut microbes profoundly influence host innate immune pathways that support arterial thrombus growth. The gut microbiota promotes arterial thrombus format...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
BL Abstract BACKGROUND: Kidney transplantation is associated with increased cardiovascular risk. Endothelial dysfunction and vascular inflammation contribute to negative outcome. In experimental models, mineralocorticoid receptor antagonists (MRA) improved endothelial function and reduced inflammation. The current study tested the hypothesis that the MRA spironolactone improves endothelial function and reduces vascular inflammation in renal transplant patients. METHODS: 80 renal transplant patients from an ongoing, double-blind randomized placebo-controlled trial were included. Paired plasma samples before a...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
ConclusionsThese observed relationships between particle exposure and inflammatory markers may indicate an increased risk of cardiovascular disease among foundry workers with high particulate exposure.
Source: International Archives of Occupational and Environmental Health - Category: Occupational Health Source Type: research
CONCLUSION: There appears to be a time-dependent variation in procoagulant factor levels in preterm newborns. Although the clinical significance remains unclear, prothrombotic factors vWF and FVIII are significantly higher in non-O blood-type preterm neonates in the third week of life. PMID: 31158844 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Gastrointestinal bleeding (GIB) is a common and often challenging issue among continuous flow left ventricular assist device (LVAD) recipients. These patients are predisposed to GIB due to a combination of anticoagulation and antiplatelet effects, one of which is an acquired von Willebrand syndrome. Studies have shown that up to 65% of LVAD recipients experience GIB, most commonly due to arteriovenous malformation (AVM) in the upper GI tract. Anticoagulation with a goal International Normalized Ratio (INR) 1.5-2.5 is mandatory in patients with LVAD to prevent device thrombosis, but can predispose to GIB.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday abstract Source Type: research
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