Cytotoxic eudesmane sesquiterpenes from Crepis sancta

Publication date: October 2019Source: Phytochemistry Letters, Volume 33Author(s): Sherif S. Ebada, Dina H. El-Kashef, Werner E.G. Müller, Peter ProkschAbstractChemical exploration of Crepis sancta (L.) Bornm. (Asteraceae) aerial parts afforded two new eudesmane sesquiterpenes (1 and 2) together with three known congeners (3-5) and two known methylated flavonoids (6 and 7). Structure elucidation of the new compounds was unambiguously performed based on HRESIMS, 1D and 2D NMR spectroscopic analyses. All isolated compounds were subjected to an in vitro cytotoxicity assay against mouse lymphoma (L5178Y) cells, revealing moderate activities with IC50 ranging from 7.9 to 21.0 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research