Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection.

Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection. Adv Exp Med Biol. 2019 Jul 19;: Authors: Lambert EE, Buisman AM, van Els CACM Abstract Pertussis remains endemic in vaccinated populations due to waning of vaccine-induced immunity and insufficient interruption of transmission. Correlates of long-term protection against whooping cough remain elusive but increasing evidence from experimental models indicates that the priming of particular lineages of B. pertussis (Bp) specific CD4+ T cells is essential to control bacterial load. Critical hallmarks of these protective CD4+ T cell lineages in animals are suggested to be their differentiation profile as Th1 and Th17 cells and their tissue residency. These features seem optimally primed by previous infection but insufficiently or only partially by current vaccines. In this review, evidence is sought indicating whether infection also drives such superior Bp specific CD4+ T cell lineages in humans. We highlight key features of effector immunity downstream of Th1 and Th17 cell cytokines that explain clearing of primary Bp infections in naïve hosts, and effective prevention of infection in convalescent hosts during secondary challenge. Outstanding questions are put forward that need answers before correlates of human Bp infection-primed CD4+ T cell immunity can be used as benchmark for the development of improved pertussis vaccines. PMID: 31321753 [PubMed - as supplied by ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Authors: Polinori I, Esposito S Abstract Pertussis is an endemic highly infectious vaccine-preventable disease. The disease is a major cause of childhood morbidity and mortality. In the most recent years, the re-emergence of pertussis occurred, and many efforts were done to identify the possible causes. Certainly, more effective laboratory methods have a role in making the diagnosis easier. However, sub-optimal efficacy of available vaccines as well as their limited duration of protection could explain the resurgence of the disease. Many forms and clinical features of the disease, ranging from the most classical to...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
22 April 2018, Cairo – This year’s World Immunization Week campaign, celebrated from 24 to 30 April, aims to highlight that protecting entire communities with vaccines protects everyone and so the theme of this year’s campaign is “Protected Together, #VaccinesWork”.  Immunization is one of the most successful and cost-effective health interventions. Studies show that every US$ 1 spent on childhood immunization returns US$ 44 in economic and social benefits.  Immunization protects everyone – from infants to senior citizens – against disabling illnesses, disability a...
Source: WHO EMRO News - Category: Middle East Health Source Type: news
Authors: Öksüz L, Gürler N, Ağaçfidan A Abstract Whooping cough is a vaccine-preventable infectious diseases caused by Bordetella pertussis/parapertussis. Despite of routine immunization programs in the world, pertussis still remains endemic. Recently unvaccinated or partially immunized infants have infected with this pathogen and also increase of incidence was observed in adolescents and adults. The source of pertussis in newborns are attributed to household, especially due to the family members. Theaim of this study was to determine B.pertussis IgG antibody positivity by ELISA method in adu...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Abstract The polyphenolic‐rich extract of Tunisian Origanum glandulosum Desf. was investigated for its phenolic composition, antioxidant activity and potential to contribute to the dietary management of type II diabetes. By mean of an ultra‐performance liquid chromatography‐electrospray ionization‐ mass spectrometry (UPLC‐PDA‐ESI‐MS) 16 phenolics were characterized. The major detected compounds are caffeic acid, luteloin glucoside, xanthomicrol and carvacrol. The polyphenolic‐rich extract presented a notable antioxidant activity similar to that of the synthetic antioxidant Trolox. It was found to inhibit, i...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: Full Article Source Type: research
This study aimed to assess the safety and efficacy of two such vaccines, one against one serogroup (serogroup C) and the other a quadrivalent vaccine targeting four serogroups (A, C, Y and W). Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reactionBordatella pertussis, the causative organism leading to whooping cough, represents a considerable public health concern in Canada. However, the current method of detection of B pertussis may also lead to a positive result when other Bordatella strains, which do not represent a public health risk, are present...
Source: Canadian Journal of Infectious Diseases and Medical Microbiology - Category: Infectious Diseases Source Type: research
Conclusions: B. pertussis is responsible for an important proportion of whooping cough in hospitalized children in Cajamarca. Epidemiologic surveillance programs for B. pertussis are essential in Peru, especially in children who could most benefit from the vaccine.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Nothing says First World city like Seattle does. Come for the cachet, stay for the Seahawks, and give a nod to the Starbucks and the Amazon and the mothership that is Microsoft just to the east. There’s nothing this so-hip-it-hurts town lacks, it seems—except perhaps for common sense. If you’re looking for that, the developing world is a far better bet. That’s the inescapable conclusion on what should be a very good week for public health—and childhood health in particular—with the World Health Organization and other groups announcing on July 24 that Nigeria has gone a full year without ...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized anti-vaxxers Nigeria polio Seattle vaccines Source Type: news
Authors: Terry JB, Flatley CJ, van den Berg DJ, Morgan GG, Trent M, Turahui JA, Greenwood MC, Corben PW, Bell GJ Abstract Bordetella pertussis (whooping cough) is an endemic, highly contagious bacterial respiratory infection, which is notifiable to Australian state and territory health departments. Between 2008 and 2011 there was a substantial outbreak in New South Wales with an initial increase in cases occurring in North Coast New South Wales from late 2007. During September and October 2011 the North Coast Public Health Unit conducted a household study of secondary attack rates to assess the effectiveness of per...
Source: Communicable Diseases Intelligence Quarterly Report - Category: Infectious Diseases Tags: Commun Dis Intell Q Rep Source Type: research
It is dismaying that fears and misinformation about vaccines have led the scourge of measles to return in the United States some 15 years after it had been officially eradicated here. And it's especially discouraging to see some early 2016 presidential hopefuls such as Chris Christie and Rand Paul pander on the issue rather than taking a strong evidence-based stance because the facts could not be more clear: Vaccines are safe and they save lives. One of the tragic aspects of this story is that some of the 102 measles cases so far this year in the United States have struck children under a year old who are too young to rec...
Source: Science - The Huffington Post - Category: Science Source Type: news
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