Efficacy of methylprednisolone on T-2 toxin-induced cardiotoxicity in vivo: a pathohistological study

Publication date: Available online 19 July 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Vesna Jaćević, Wu Qinghua, Eugenie Nepovimova, Kamil KučaAbstractOur aim was to compare the protective efficacy of two different formulations of methylprednisolone in T-2 toxin-induced cardiomyopathy. Methylprednisolone (soluble form, Lemod-solu® and/or depot form, Lemod-depo®, a total single dose of 40 mg/kg im) was given immediately after T-2 toxin (1 LD50 0.23 mg/kg sc). The myocardial tissue samples were examinated by using histopathology, semiquantitative and imaging analyses on day 1, 7, 14, 21, 28 and 60 of the study. Therapeutic application of Lemod-solu® significantly decreased the intensity of myocardial degeneration and haemorrhages, distribution of glycogen granules in the endo- and perimysium, a total number of mast cells and the degree of their degranulation was in correlation with the reversible heart structural lesions (p 
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research

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We present two young patients (
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
In this study, H9c2 cells a type of rat cardiac myoblasts, were used as model cardiac muscle cells. The use of a lipid composition used to prepare the β-MEND (where MEND denotes multifunctional envelope-type nano device) permitted the particles to be efficiently internalized by H9c2 cells, as evidenced by flow cytometry analyses. Intracellular observations by confocal laser scanning microscopy showed that the β-MEND efficiently accumulated in mitochondria of H9c2 cells. We also constructed an RP/β-MEND that contained a mitochondrial RNA aptamer to achieve mitochondrial delivery in H9c2 cells. The successful ...
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
Conditions:   Inherited Cardiac Arrhythmias;   Long QT Syndrome;   Arrhythmogenic Right Ventricular Cardiomyopathy;   Brugada Syndrome;   Catecholaminergic Polymorphic Ventricular Tachycardia Intervention:   Sponsors:   University of British Columbia;   Kingston Health Sciences Centre;   Quebec Heart Institute;   Montreal Heart Institute Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The pathogenesis and cardiovascular impact of type 2 diabetes (T2D) may be different in South Asians compared with other ethnic groups. The phenotypic characterization of diabetic cardiomyopathy remains debate...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
ConclusionsThese models predict the risks of mortality and HF hospitalization in patients with HFpEF and emphasize the importance of health status data in determining prognosis. (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist [TOPCAT]; NCT00094302)Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: October 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 10, SupplementAuthor(s): C. Blakely, R. Hart, G. VanDam, L. Smith, M. Hazell, D. Campbell, P. Branscombe, H. Abdollah
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: October 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 10, SupplementAuthor(s): A. Zhu, H. Bews, D. Cheung, R. Nagalingam, I. Mittal, V. Goyal, C. Asselin, I. Kirkpatrick, M. Czubryt, D. Jassal
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsWe describe a unique and novel cellular model that provides insight into the mitochondrial abnormalities present in DCMA and identifies SS-31 as a potential therapeutic for this devastating disease.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Abstract The finding of pulmonary hypertension (PH) by echocardiography is common and of concern. However, echocardiography is just a suggestive and non-diagnostic assessment of PH. When direct involvement of pulmonary circulation is suspected, invasive hemodynamic monitoring is recommended to establish the diagnosis. This assessent provides, in addition to the diagnostic confirmation, the correct identification of the vascular territory predominantly involved (arterial pulmonary or postcapillary). Treatment with specific medication for PH (phosphodiesterase type 5 inhibitors, endothelin receptor antagonists and prostacycl...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Pediatric heart failure remains poorly understood, distinct in many aspects from adult heart failure. Limited data point to roles of altered mitochondrial functioning and in particular, changes in mitochondrial lipids, especially cardiolipin. Barth syndrome is a mitochondrial disorder caused by tafazzin mutations that lead to abnormal cardiolipin profiles. Patients are afflicted by cardiomyopathy, skeletal myopathy, neutropenia, and growth delay. A mouse model of Barth syndrome was developed a decade ago, which relies on a doxycycline-inducible shRNA to knock down expression of tafazzin mRNA ("TAZKD&...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
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