Treatment of second to third-degree burns in a 2-day-old infant: A case report

ConclusionThere is evidence that newborns have a much higher potential for wound healing than adults. Proper position in long-term immobilization of toes is important to prevent scar contracture and deformity.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research

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Introduction: Options for therapy of severe burns are limited and generally include local wound care, debridement, grafting, and long-term care. Mesenchymal stem cells (MSCs) have been used in applications directed at the repair and regeneration of damaged tissue. There is little known regarding the clinical application of allogenic MSCs in the treatment of second degree burn injury. This pilot study establishes the safety of MSC therapy for burn wounds in two dose escalations, in addition to providing both observational and objective data that this treatment protocol improves the healing of these injuries.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Thermal injury leads to loss of the regenerative capacity of the skin and scarring becomes a significant risk, due to the inability to emulate normal skin architecture and adnexal structures. Mesenchymal stem cells (MSC) have been used in a variety of clinical applications to repair and regenerate damaged tissue. MSC ’s can stimulate cellular processes such as fibroblast proliferation, migration, and endothelial angiogenesis, as well as modulate the host’s immune response to favor more optimal wound healing.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Conclusions Our results suggest that CFSCs are associated with the inhibition of fibrosis in HSFs by a paracrine effect. The use of CFSC-CM may be a novel therapeutic strategy for HSs.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
We describe an isolation method, characterize a population, and investigate its potential for cell banking and thus suitability as a potential product for cell grafting therapies. Our results show hFDF and a bone marrow-derived mesenchymal stem cell (BM-MSC) line shared identification markers and in vitro multilineage differentiation potential into osteogenic, chondrogenic, and adipogenic lineages. The hFDF population exhibited similar cell characteristics as BM-MSC while producing lower pro-inflammatory cytokine IL-6 levels and higher levels of the wound healing factor hepatocyte growth factor. We demonstrate in vitro dif...
Source: Cell Transplantation - Category: Cytology Authors: Tags: Cell Transplant Source Type: research
Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineag...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Publication date: Available online 2 August 2019Source: BurnsAuthor(s): Jae Hyek Choi, Corina Necsoiu, Daniel Wendorff, Bryan Jordan, Alexander Dixon, Teryn R. Roberts, Brendan M. Beely, Leopoldo C. Cancio, Andriy I. BatchinskyAbstractBackgroundWe investigated effects of mesenchymal stem cells (MSC) or low-flow extracorporeal life support (ECLS) as forms of adjunct treatment for acute respiratory destress syndrome (ARDS) due to smoke inhalation injury (SII) and 40% TBSA burns by assessing their effects on histological injury scores. We hypothesized that adjunct treatments decrease histological end-organ damage.MethodsAnest...
Source: Burns - Category: Dermatology Source Type: research
Radiation accidents are rare, but can produce large numbers of casualties with predictable patterns of injury. Casualties may suffer from a wide range of radiation exposures. Triage based on presence or absence of conventional injuries and an accurate assessment of radiation dose based on event history, symptoms, and laboratory testing, is critical. Treatment of acute radiation syndrome is supportive: including fluids, antibiotics, blood products, colony-stimulating factors, and stem cell or bone marrow transplantation. Care of radiation-injured patients with conventional trauma or burns needs to be modified to account for...
Source: Critical Care Clinics - Category: Intensive Care Authors: Source Type: research
(Newcastle University) The first clinical trial in humans of a revolutionary approach to treating chemical burns in the eye begins. It uses a tissue-softening enzyme to soften the wounded areas and promote the patient's own stem cells into repairing the damage.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Authors: Şovrea AS, Boşca AB, Constantin AM, Dronca E, Ilea A Abstract Nowadays, adipose tissue appears to be the most valuable source in regenerative cell therapy, due to the following characteristics: high accessibility, high expression in a large number of individuals, high self-renewal and ability to differentiate, and hematopoietic support to the implant area. Its therapeutic potential has been experimentally observed in a broad spectrum of diseases with high population impact: diabetes, myocardial infarction, Parkinson disease, bone fractures, facial reconstruction or loss of subcutaneous tissue due to cong...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
By Katie Hunt, CNN (CNN) — Drinking coffee could activate the body’s fat-fighting defenses, a discovery that could have potential implications in the battle against obesity and diabetes. In a study published Monday, researchers at the University of Nottingham said that coffee may help stimulate our brown fat reserves, also known as brown adipose tissue, which play a key role in how quickly we can burn calories. There are two forms of fat cells, brown cells and white cells, and each plays a different role in our metabolism. While brown cells help generate heat, white cells are responsible for the storage of...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Coffee Source Type: news
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