Rituximab Treatment Modulates the Release of Hydrogen Peroxide and the Production of Proinflammatory Cytokines by Monocyte at the Onset of Type 1 Diabetes.

Rituximab Treatment Modulates the Release of Hydrogen Peroxide and the Production of Proinflammatory Cytokines by Monocyte at the Onset of Type 1 Diabetes. Endocr Metab Immune Disord Drug Targets. 2019;19(5):643-655 Authors: Hamouda L, Miliani M, Hadjidj Z, Messali R, Aribi M Abstract BACKGROUND: Monocytes are the main blood innate mononuclear phagocyte and one of the most important effector cells expressing Fcγ receptor, which is critical for the interaction with Fc domain of antibodies. OBJECTIVE: To evaluate the effect of Rituximab (RTX, a chimeric human anti-CD20 monoclonal antibody) on the functional activities of Monocytes (MOs) at the onset of human Type 1 Diabetes (T1D). METHODS: MOs were isolated from peripheral blood mononuclear cells (PBMCs) obtained from volunteer patients with recent-onset T1D and healthy control donors. RESULTS: The levels of the production of Interleukin 1β (IL-1β) and IL-6 were significantly increased in MOs from patients with T1D when compared to MOs from healthy controls (respectively, p
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

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Condition:   Diabetes Mellitus, Type 1 Interventions:   Biological: Mesenchymal Stem Cells (MSCs);   Other: Placebo Infusion (Plasmalyte A with 0.5% human serum albumin) Sponsors:   Medical University of South Carolina;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsThe above mention data demonstrated that the hematological profile showed noticeable alterations in children with T1DM and the inflammation and oxidative stress markers were contributed to the hematological abnormalities. The results revealed that some hematological indices can be used in the early detection of T1DM children at risk of diabetic complications.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractBackgroundThyroid dysfunction (TD) occurs in 13.4% of diabetic patients, which has prompted recommendations for annual thyroid screening in patients with diabetes. However, recommendations for annual screening should be based on disease incidence rather than prevalence.MethodsIn 1997 –1998, seven hundred and thirty patients (618 type 2 diabetes, 55% male; 112 type 1 diabetes, 47% male) were sequentially screened for TD. The 639 patients with normal thyroid function were followed from 1999 to 2006, with annual thyroid function tests.ResultsA total of 21/112 (19%) with type 1 diabetes (T1DM) and 70/618 (11%) wi...
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Publication date: Available online 15 August 2019Source: Life SciencesAuthor(s): Xuelian Li, Zhiyang Li, Bingong Li, Xianjie Zhu, Xingjun LaiAbstractAimsNLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.Main methodsA streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were eva...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 1 October 2019Source: Life Sciences, Volume 234Author(s): Catarina Marques, Andreia Gonçalves, Patrícia Manuela Ribeiro Pereira, Daniela Almeida, Beatriz Martins, Carlos Fontes-Ribeiro, Flávio Reis, Rosa FernandesAbstractAimsOxidative stress has been linked to the development and progression of diabetic nephropathy (DN). The present study evaluated whether the dipeptidyl peptidase-4 inhibitor sitagliptin attenuates glomerular lesions and oxidative stress evoked by chronic hyperglycemia, by a mechanism independent of insulin secretion and glycemia normalization.Main methodsA rat model ...
Source: Life Sciences - Category: Biology Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0977-2667 Objective The quality report of the disease management programmes of North Rhine Westphalia 2016 showed prevalences for long-term complications (neuropathy, nephropathy, retinopathy) of less than 30% for people with diabetes type 1 (DM1) and type 2 (DM2). The aim of this study was to assess risk expectations and fear regarding long-term complications of diabetes in people with DM1 and DM2. Methods We assessed risk expectations and fear regarding diabetes complications in people with DM1 (n=110) and DM2 (n=143 without insulin, n=249 with insulin) visiting an University o...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
This study aimed to explore the total burden of hospitalization in individuals with diabetes
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
In this study, there were significant differences between diastolic function parameters of the heart. The mitral isovolumic contraction time, contraction time, and isovolumic relaxation time values were different in the patients than in the controls (p
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
M. Yassine For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis (HSK), celiac disease (CD), and multiple sclerosis (MS). Best examples of viral infections that have been proposed to modulate the induction and development of autoimmune diseases are the infections with enteric viruses such as Coxsackie B virus (CVB) and rotavirus, as well as influenza A viruses (IAV), and herpesviruses. Other viruses that ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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