SRC-3/AIB-1 Enhances Hepatic NFATC1 Transcription and Mediates Inflammation in a Tissue-Specific Manner in Morbid Obesity.

CONCLUSIONS: Steroid receptor coactivators are critical regulators of human metabolism with pleiotropic and tissue-specific actions. We believe that our study will contribute to the better understanding of the complex multi-tissue interactions that are disrupted in obesity and can therefore lead in numerous cardiometabolic diseases. Further on, present findings suggest that SRC-3/AIB-1 could constitute possible future drug targets. PMID: 31322077 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

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The objective of this study was to determine if a modest weight loss of ≥10% of initial body weight is enough to improve outcomes in overweight or obese patients with established AF. We performed an extensive literature search and systematic review of studies that compared weight loss of ≥10% versus weight loss of less than 10% or weight gain and assessed outcomes i ncluding recurrence of AF as determined via a Holter monitor, AF burden and improvement in AF symptom severity.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Tags: Systematic Review and Meta-Analysis Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
With the obesity epidemic expanding in the general population, orthopedic surgeons are encountering an increasing number of obese trauma patients. Caring for the obese trauma population requires tailoring of current practices to optimize care at each stage of management. Conflicting research on the effect of obesity on trauma outcomes impacts standardization of treatment practices for this population [1,2]. In general, obesity is a poor prognostic factor in orthopedic surgery. However, the effect of obesity on specific clinical outcomes after orthopedic trauma is largely unknown, as patients presenting with particular frac...
Source: Injury - Category: Orthopaedics Authors: Source Type: research
The United States is in an obesity epidemic. Obesity has multiple common comorbid conditions, including lower extremity arthritis. We sought to examine the course of treatment for a population with body mass index (BMI) ≥ 40 kg/m2 and osteoarthritis (OA) of the hip or knee. We investigated decision criteria that influenced arthroplasty surgeons to recommend non-operative management versus total joint arthroplasty (TJA). For those patients who ultimately received TJA, we compared outcomes in this population to tho se with BMI
Source: The Journal of Arthroplasty - Category: Orthopaedics Authors: Source Type: research
Title: America's Obesity Epidemic May Mean Some Cancers Are Striking SoonerCategory: Health NewsCreated: 8/14/2019 12:00:00 AMLast Editorial Review: 8/15/2019 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Oncology, Geriatrics, Nutrition, News, Source Type: news
WEDNESDAY, Aug. 14, 2019 -- Since the turn of the century, American obesity rates have skyrocketed. And now a new study indicates that as the nation's waistlines expand, cancers long linked to obesity are striking the middle-aged more than ever...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusion: The prevalence of obesity and overweight in adolescents requires the implementation of effective programs to fight this epidemic. Health education targeting peers and their parents, peer education, screening of risk groups, and controlling the sale of unhealthy foods can be some interventions.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Cancer immunotherapy has been heralded as a breakthrough cancer treatment demonstrating tremendous success in improving tumor responses and survival of patients with hematological cancers and solid tumors. This novel promising treatment approach has in particular triggered optimism for triple negative breast cancer (TNBC) treatment, a subtype of breast cancer with distinct clinical features and poor clinical outcome. In early 2019, the FDA granted the first approval of immune checkpoint therapy, targeting PD-L1 (Atezolizumab) in combination with chemotherapy for the treatment of patients with locally advanced or metastatic...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study aimed to evaluate the prevalence of hypoandrogenemia and associated risk factors in this population. METHODS: This cross-sectional study included 266 nondiabetic men 
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
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