Enhancement characteristics of retroperitoneal lymphomatous lymph nodes.
ConclusionThe comparison of enhancement curves of retroperitoneal LLN with retroperitoneal control nodes showed a marked similarity with and substantiates our previous findings in lymph nodes of the neck and of the mediastinum. The best diagnostic accuracy was achieved by combining the parameters peak contrast value and time to peak and adjusting these values to the body weight. Peak enhancement of the retroperitoneal LLN was higher and arrived earlier than that of the mediastinal nodes from the previous investigation. PMID: 23446747 [PubMed - as supplied by publisher]
ConclusionPlerixafor proved effective to mobilize adequate numbers of PBSCs in individual patients with relapsed malignancies after prior single or tandem HDC+PBSCT. These PBSCs could establish sustained multi-lineage hematopoietic engraftment without any sequelae.
In conclusion, the anti-proliferative effects of SFN indicate its potential as a new substance for the treatment of PEL. PMID: 31787726 [PubMed - in process]
This report strengthens the hypothesis of a common lymphoid progenitor which accumulates genetic alterations leading to two different hematologic malignant diseases with significa ntly distinct prognoses.
Publication date: Available online 9 November 2019Source: Pharmacology &TherapeuticsAuthor(s): Wen-juan Liu, Yue Du, Ru Wen, Ming Yang, Jian XuAbstractRapidly developing molecular biology techniques have been employed to identify cancer driver genes in specimens from patients with non-small cell lung cancer (NSCLC). Inhibitors and antibodies that specifically target driver gene-mediated signaling pathways to suppress tumor growth and progression are expected to extend the survival time and further improve the quality of life of patients. However, the health of patients with advanced and metastatic NSCLC presents signif...
AbstractHematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings. These malignancies frequently affect the gastrointestinal (GI) tract, either by secondary extranodal or extramedullary extension to the GI tract, or as a primary process arising in the GI tract. In fact, the GI tract may represent the most common extranodal site of involvement in many of them, such as lymphoma. Furthermore, in the current era of improved cancer treatment and advanced transplant procedures with increased survival, it has been quite c...
Conditions: Lymphoma; Nasopharyngeal Cancer; Esophageal Cancer; Cervical Cancer; Hepatobiliary Cancer; Pancreatic Cancer; Sarcoma; Prostate Cancer Intervention: Diagnostic Test: PET/MR scan Sponsor: Tel-Aviv Sourasky Medical Center Not yet recruiting
ConclusionHistology spectrum of jejunal tumors are distinct. Difficulty in obtaining preoperative tissue diagnosis of these lesions need to be addressed by improved endoscopic and image-directed biopsy techniques.
Publication date: Available online 5 November 2019Source: Stem Cell ResearchAuthor(s): Mireia Castillo-Martin, Nataliya Gladoun, Dan Han, Adolfo Firpo-Betancourt, Jose M. Silva, Carlos Cordon-CardoAbstractThe last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, but solid neoplasms may also develop, which in certain instances are donor-derived. It has also been well d...