Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.

Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer. Mol Biol Rep. 2019 Jul 18;: Authors: Orhan C, Bulut P, Dalay N, Ersen E, Buyru N Abstract Transcription Elongation Factor A-like 7 (TCEAL7) was first reported as a candidate tumor suppressor gene because of its inactivation in ovarian cancer as a result of promoter methylation. Down-regulation of the TCEAL7 gene expression was also associated with other cancers such as endometrial, breast, brain, prostate, gastric cancers, glioblastoma and linked to tumor phenotypes and clinical outcomes. However, there is no report in the literature investigating the role of TCEAL7 in non-small cell lung cancer. Cyclin D1 is an important molecule in the transition from G1 to S phase of the cell cycle, and is frequently deregulated in cancers. Cylin D1 (CCND1) gene is amplified or overexpressed in a variety of tumors. In our previous study we reported that CCND1 over-expression was not associated with amplification in non-small cell lung cancer. Recently, it has been reported that TCEAL7 regulates CCND1 expression through myc-binding E-box sequences. The aim of this study was to investigate the expression of TCEAL7 gene in non-small cell lung cancer and to determine its effect on the CCND1 expression level. For this purpose, expression levels of TCEAL7 and CCND1 genes were investigated in 50 patients with non-small cell lung cancer by quantitative real time polymerase chain reacti...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research

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Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
CONCLUSIONS The effect of PL on the SDF-1-CXCR4/CXCR7 axis has become an attractive target for inhibiting angiogenesis in hepatoma cells. Our results provide more evidence for the clinical application of PL as part of traditional Chinese medicine in modern cancer treatment. PMID: 31415486 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, quantitative evaluation of the performance of the method proved its improved accuracy compared to other current state-of-art techniques, and it showed robust performance even with noise and a narrow overlapping region between adjacent fields.
Source: Micron - Category: Biology Source Type: research
In conclusion, this study recognized linc00460 as a new oncogenic lncRNA in OS and suggests that the linc00460/miR-1224-5p/FADS1 axis might be a potential therapeutic target for OS.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 August 2019Source: Journal of Theoretical BiologyAuthor(s): M. Chowkwale, G.J. Mahler, P. Huang, B.T. MurrayAbstractEndothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with embryonic development, this process has since been shown to occur in adult tissue remodeling including wound healing, fibrosis, and cancer. In an attempt to understand the role of EndMT in cancer progression and meta...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Mengyao Zhao, Liming Gu, Yun Li, Shumin Chen, Jiangshan You, Liqiang Fan, Yudong Wang, Liming ZhaoAbstractGynecological cancers are the most commonly diagnosed forms of cancer among the female population. Chitooligosaccharides (COS)—hydrolysis products from chitosan—display high bioavailability, high water solubility, and low molecular weight properties. Here, we investigated the influence of COS on 11 gynecological tumor cell types, and subsequently elucidated molecular mechanisms through which the observed inhibition occurre...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 17 August 2019Source: PolymerAuthor(s): Sakineh Hajebi, Amin Abdollahi, Hossein Roghani-Mamaqani, Mehdi Salami-KalajahiAbstractSmart drug-delivery systems based on stimuli-responsive polymers are extensively studied because of their advantages in controlled release of anti-cancer drugs in response to induced stimuli. To develop a smart drug-delivery system, silica nanoparticles modified with 3-(trimethoxysilyl) propyl methacrylate (MPS) were used in inverse emulsion polymerization of N,N-dimethylaminoethyl methacrylate with N,N-methylene bisacrylamide in different amounts (MBA: 2, 4, and ...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s):
Source: New Scientist - Category: Science Source Type: research
ConclusionsWe obtained health utility and HRQoL scores of Japanese PC patients stratified by disease progression in detail. Our results will be useful for establishing cost-effectiveness analyses in Japanese PC settings.
Source: Quality of Life Research - Category: Health Management Source Type: research
Publication date: Available online 17 August 2019Source: European UrologyAuthor(s): Gregory J. Nason, Michael A.S. Jewett, Robert J. Hamilton
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