CD8+ T-cells Negatively Regulate Inflammation Post-Myocardial Infarction.

In conclusion, despite having improved cardiac physiology and overall survival, CD8atm1Mak mice had increased innate inflammation and poor scar formation leading to higher incidence of cardiac rupture. Our data suggest that the role of CD8+ T-cells in post-MI recovery may be both beneficial and detrimental to cardiac remodeling and is mediated via a cell-specific mechanism. PMID: 31322426 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research