Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy.

Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Jul 19;: Authors: Salavatian S, Yamaguchi N, Hoang JD, Lin N, Patel S, Ardell JL, Armour JA, Vaseghi M Abstract Mechanisms behind development of premature ventricular contraction (PVC)-induced cardiomyopathy remain unclear. PVCs may adversely modulate the autonomic nervous system to promote development of heart failure. Afferent neurons in the inferior vagal (nodose) ganglia transduce cardiac activity and modulate parasympathetic output.Effects of PVCs on cardiac parasympathetic efferent and afferent neurotransmission are unknown. The purpose of this study was to evaluate effects of PVCs on parasympathetic afferent neurotransmission and compare these effects to a known powerful autonomic modulator, myocardial ischemia.In 16 pigs, effects of variably-coupled PVCs on heart rate variability (HRV) and parasympathetic afferent neurotransmission were evaluated. Direct nodose neuronal recordings were obtained in-vivoand cardiac-related afferent neurons were identified based on their response to cardiovascular interventions, including ventricular chemical and mechanical stimuli, left anterior descending (LAD) coronary artery occlusion, and variably-coupled PVCs. On HRV analysis before vs. after PVCs, parasympathetic tone decreased (normalized HF:...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research