Comprehensive Real-World Assessment of Marketed Medications to Guide Parkinson ’s Drug Discovery

ConclusionsArmodafinil, modafinil, and methylphenidate were associated with a decreased risk of parkinsonism, as were β-agonists. Of the β-blockers, only propranolol was associated with increased risk. Healthcare database analyses that incorporate scientific rigor provide insight and direction for drug discovery efforts. These findings show association not causality; however, they offer considerable support to th e association between β-adrenergic receptor modulation and risk of Parkinson’s disease.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research

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CONCLUSIONS: The results of this study showed that the Persian version of PD-CRS is a reliable and valid measure with high sensitivity and specificity to identify MCI and dementia in patients with PD. Implications for rehabilitation The PD-CRS has an excellent test-retest and inter-rater reliability and validity in Iranian patients with PD. The PD-CRS has high sensitivity and specificity for discriminating between different levels of cognitive impairment (i.e. no cognitive impairment, mild cognitive impairment, and dementia) in Iranian patients with PD. PMID: 32924645 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
CONCLUSIONS: PD patient sleep problems were associated with caregiver sleep problems, leading to increased burden in caregivers and poorer life satisfaction. The findings highlight a potential opportunity for empirically supported sleep interventions. Implications for rehabilitation Parkinson's disease is a progressive neurological condition that impacts patient and caregiver quality of life. Patient sleep problems contribute to greater caregiver burden, sleep problems, and reduced life satisfaction. The findings suggest patient and caregiver sleep may be a worthwhile target for intervention in order to reduce risk of care...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
ABSTRACTPurposeImpaired olfactory function is one of the main features of Parkinson ’s disease. However, how peripheral olfactory structures are involved remains unclear. Using diffusion tensor imaging fiber tracking, we investigated for MRI microstructural changes in the parkinsonian peripheral olfactory system and particularly the olfactory tract, in order to seek a better unde rstanding of the structural alternations underlying hyposmia in Parkinson’s disease.MethodsAll patients were assessed utilizing by the Italian Olfactory Identification Test for olfactory function and the Unified Parkinson ’s Dise...
Source: Neuroradiology - Category: Radiology Source Type: research
There remains a significant mismatch between the complexity and variability of symptoms and disabilities in Parkinson's disease (PD), and the capabilities of existing validated assessment tools to objectively measure and monitor them. However, with the advances of circuit and sensor technologies, it is now possible to apply the concept of digital phenotyping to PD, providing a moment-by-moment quantification of individual patient phenotypes using personal digital devices, such as smartphones. Such technology holds considerable potential if a patient-centered multidisciplinary team is able to select digital outcomes that ar...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Point of view Source Type: research
Several studies suggests that the provision of auditory cues with music could be beneficial for people with Parkinson ’s Disease (PD). The aim of the study was to evaluate the effects of music-based physical therapy on the international Classification of Functioning, Disability and Health (ICF) components: disability, cognition, muscle strength, balance, and functional mobility.
Source: Journal of Bodywork and Movement Therapies - Category: Physiotherapy Authors: Tags: Prevention and Rehabilitation Source Type: research
CONCLUSIONS: Nurses can play a crucial role in the recognition and management of nOH. Nurses who are educated about nOH are well suited to partner with care providers to treat disabling motor and nonmotor symptoms of Parkinson disease.
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research
ABSTRACT Background: The instruments that measure the impact of fatigue on physical, cognitive and psychosocial aspects has yet to be validated in Brazilian population with Parkinson ’ s disease (PD). The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the Modified Fatigue Impact Scale (MFIS-PD/BR). Methods: Ninety PD individuals were recruited. The adaptation of the MFIS-PD was performed by translation and back translation methodology. Psychometric analysis was applied in order to perform the administration of the socio-clinical questionnaire, Mini-M...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Mutations in RAB39B at Xq28 causes a rare form of X-linked intellectual disability (ID) and Parkinson ’s disease. Neurofibromatosis type 1 (NF1) is caused by heterozygous mutations in NF1 occurring de novo in abou...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
"Does the Response to Morning Medication Predict the ADL-Level of the Day in Parkinson's Disease?" Parkinsons Dis. 2020;2020:7140984 Authors: Hørmann Thomsen T, Kjær TW, Bastrup Jørgensen L, Haahr A, Winge K Abstract Background: Individuals with Parkinson's Disease (PD) have bradykinesia during mobility tasks in the morning before intake of dopaminergic treatment and have difficulties managing Activities of Daily Living (ADLs). Early morning off (EMO) refers to off-states in the morning where the severity of bradykinesia is increased and causes a decrease in mobility relat...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
This article investigates the intimate partner violence among caregivers and persons with Parkinson's disease (PD). We u...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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