213 Bi production and complexation with new picolinate containing ligands

AbstractBinding of bismuth cation with two newly synthesized picolinate containing acyclic (L1) and macrocyclic (L2) ligands was studied. Both ligands demonstrate complex formation with Bi3+ under ambient conditions with high complexation constants. Serum stability of the complexes was investigated in serum protein excess of 10- and 100-times. Experiments with no-carrier-added radiobismuth (207Bi and213Bi) were performed. A one-column225Ac/213Bi generator system, based on Ac resin (Triskem Inc.), was tested. The overall yield of213Bi was exceeding 85% with225Ac breakthrough below 10−4%.
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research