Oxidative metabolism alterations in the emotional brain of anxiety-prone rats

Publication date: Available online 19 July 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Chelsea R. McCoy, Mohammad N. Sabbagh, Jonathan P. Huaman, Alicia M. Pickrell, Sarah M. ClintonAbstractMood disorders such as anxiety and depression are heterogeneous disorders with many sufferers unresponsive to current pharmacological treatments. Individual differences in temperament represent one factor that may underlie symptom heterogeneity, so understanding its biological underpinnings can help pave the way to personalized therapies and improved patient outcomes. The present study uses a rodent model of temperamental differences to examine whether individual differences in emotional behavior phenotypes correspond to altered limbic brain cellular metabolism, an indicator of neuronal activity. The model uses two selectively bred rat strains – high novelty responder rats (HRs) that show highly exploratory behavior in a novel environment, active coping style and resilience to chronic mild stress compared to low novelty responder rats (LRs), which are inhibited in novel environments, display passive coping style, and are susceptible to chronic stress. Utilizing transcriptome data from a prior study in adult HR/LR rats, we first show that a preponderance of genes differing in the HR vs. LR hippocampus and amygdala are involved in cellular metabolism. This led us to then ask if oxygen consumption was altered in isolated mitochondria of the hippo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research

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Abstract Pancreatic cancer is associated with a poor prognosis and high mortality. Thus, distress that includes depression and anxiety is a relatively common comorbidity for patients suffering from pancreatic cancer. However, these psychological symptoms are likely to be under-detected and undertreated. Regarding high levels of unmet needs of psychological support for patients with pancreatic cancer, early screening for distress and adequate interventions should be considered in palliative care settings. Suicide, a common but preventable cause of mortality for patients with pancreatic cancer, also deserves the fur...
Source: Korean J Gastroenter... - Category: Gastroenterology Authors: Tags: Korean J Gastroenterol Source Type: research
We examined 969 patients, at least 6 months after myocardial infarction or coronary revascularisation. Depression or anxiety was assessed using a standard HADS (Hospital Anxiety and Depression Scale), while QoL by SF-36 (Short-Form-36 Questions) questionnaires. Follow-up was done to assess mortality in incidence of non-fatal cardiovascular event. Results: Both mood disorders were rather frequent; borderline depression or anxiety (HADS score 8-10) had 14.8 or 10.9% of patients, respectively; moderate-to-severe depression or anxiety (HADS score ≥11) had another 8.2 or 6.7% of patients. After adjustment for potentia...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Conclusion: No clinically relevant effects on cognitive or emotional function were found of individualized regular coaching for physical activity and exercise. However, increased adherence to the intervention was associated with improved cognitive function. PMID: 31440765 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
This week’s Psychology Around the Net provides tips for kicking off a healthy school year, creative prompts to help you deal with anxiety, news about a possible link between children’s language and mental health, and more. Happy reading! Tips For A Successful 2019 School Year: Many schools went back in session this week; some were already in full swing! Jim Holsomback presents a handy guide on tips for a great start, sample conversation starters to help you engage with your kid and stay in the loop, and several mental health resources for parents and children. These College Students Are Far More Prone to Serio...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net anxiety art Children cisgender Creativity Fear gender nonconforming genderqueer Genetics kids Language Skills Liz Beecroft nikes nonbinary Prince William School Transgender Source Type: blogs
BACKGROUND: Adolescence is characterized by an increased vulnerability for internalizing psychopathologies such as depression and anxiety. A positive association between anxiety and depression has consistently been found in research. However, the specific ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
ConclusionThe TELEREH-HF trial will provide novel data on the effects of telerhabilitation on hospitalization and mortality in HF patients, and on safety, qaulity of life, depression, anxiety and acceptance of and adherence to this intervention.
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 22 August 2019Source: The Lancet PsychiatryAuthor(s): Meng-Chuan Lai, Caroline Kassee, Richard Besney, Sarah Bonato, Laura Hull, William Mandy, Peter Szatmari, Stephanie H AmeisSummaryBackgroundCo-occurring mental health or psychiatric conditions are common in autism, impairing quality of life. Reported prevalences of co-occurring mental health or psychiatric conditions in people with autism range widely. Improved prevalence estimates and identification of moderators are needed to enhance recognition and care, and to guide future research.MethodsIn this systematic review and meta-analysis...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Bruno Kusznir Vitturi, Bruno Azeredo Coutinho Nascimento, Beatriz Rizkallah Alves, Felipe Sobolewski Carneiro de Campos, Dawton Yukito TorigoeAbstractBackgroundNeurological manifestations of Rheumatoid Arthritis (RA) are usually uncommon. However, a number of recent studies have reported that the burden of cognitive impairment in RA could be significant. We sought to explore the prevalence and clinical predictors of cognitive impairment in persons with RA.MethodsThis is a cross-sectional case-control study with patients with...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
According to USAToday, nearly 21 million Americans struggle with substance addictions. That’s more than the number of people who have all cancers combined, and can mean 1 in 7 people will eventually suffer from an addiction. With such an epidemic in place, it is important to understand how the process of healing from an addiction works. This means learning what types of luxury treatment programs are available and asking questions like, how long is a luxury treatment program? Typically, luxury treatment programs can last anywhere from 30-90 days, depending on many factors. What Determines How Long a Luxury Treatment ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Drug Rehab Information luxury luxury drug rehabilitation luxury heroin rehab rehab center rehabilitation for drug addiction residential residential rehab Source Type: blogs
APA is speaking out against the Trump administration ’s attempt to nullify a longstanding legal settlement that limits the time that migrant children can be kept in detention.The Department of Homeland Security today issued arule that seeks to replace the Flores Settlement Agreement, the federal consent decree that has set basic standards for the detention of migrant children and teenagers by the United States since 1997. The new rule could expand family detention and increase the time children spend in custody.According to a report inThe Washington Post, Homeland Security officials said the rule would eliminate a 20...
Source: Psychiatr News - Category: Psychiatry Tags: detention of immigrant children Flores settlement replacement of Flores agreement Trump administration Source Type: research
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