Minthostachys verticillata essential oil activates macrophage phagocytosis and modulates the innate immune response in a murine model of Enterococcus faecium mastitis

Publication date: Available online 19 July 2019Source: Research in Veterinary ScienceAuthor(s): Ivana Dalila Montironi, Elina BeatrizReinoso, Valentina Croce Paullier, María Inés Siri, María Julia Pianzzola, Melina Moliva, Noelia Campra, Guillermo Bagnis, Isabel Ferreira LaRocque-de-Freitas, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima, José María Raviolo, Laura Noelia CariddiAbstractMinthostachys verticillata essential oil (EO) is a natural product that reports immunomodulatory effects on human T cells as well as anti-inflammatory activity. Bovine mastitis is a worldwide disease, mainly caused by bacteria, affecting milk quality and yield, leading to high economic losses. Environmental pathogens, as Enterococcus faecium, are implicated in the disease. Antibiotic therapy is adequate, although it can leave residues in milk, causing problems in human health. The search of immunomodulatory substances for bovine mastitis treatment is a promising alternative strategy. The aim of this study was to characterize the effect of M. verticillata EO on macrophage phagocytosis and evaluate its immunomodulatory and protective effects in mice challenged with E. faecium. The results showed that EO activated macrophage phagocytosis mechanisms inducing reactive oxygen species production. Moreover, EO modulated the innate immune response in mammary glands of female Balb/c mice challenged with E. faecium decreasing the infiltration of polymorphonuclear neutrophils and IL-1β and TNF-Î...

Source: Research in Veterinary Science - July 20, 2019 Category: Veterinary Research Source Type: research