Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model

hBM ‐MSC‐derived EV injections repaired the ultrastructural damage caused by Cd for apical and basolateral membranes and mitochondria of kidney proximal tubules, glomerular podocytes in female and male medaka. AbstractTreatment modalities for kidney disease caused by long ‐term exposure to heavy metals, such as cadmium (Cd), are limited. Often, chronic, long‐term environmental exposure to heavy metal is not recognized in the early stages; therefore, chelation therapy is not an effective option. Extracellular vesicles (EVs) derived from stem cells have been demons trated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from human bone marrow mesenchymal stem cells (hBM‐MSCs) to treat Cd damage, we generated a Cd‐exposed medaka model. This model develops heavy metal‐induced cell damage in var ious organs and tissues, and shows decreased overall survival. Intravenous injection of highly purified EVs from hBM‐MSCs repaired the damage to apical and basolateral membranes and mitochondria of kidney proximal tubules, glomerular podocytes, bone deformation, and improved survival. Our system a lso serves as a model with which to study age‐ and sex‐dependent cell injuries of organs caused by various agents and diseases. The beneficial effects of EVs on the tissue repair process, as shown in our novel Cd‐exposed medaka model, may open new broad avenues for interventional strategies.
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research

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Purpose of review Pruritus is an important, prevalent but often neglected symptom in patients with advanced chronic kidney disease (CKD) or on dialysis. This review addresses the use of activated charcoal and its analogs in the treatment of uremic pruritus, which can be a sign of uremic toxicity. Recent findings When common causes are corrected and dialysis efficiency is optimized, pruritus is mainly ascribed to the retention of middle and protein-bound molecules, of which indoxyl sulfate and p-cresyl sulfate are the best studied. While hemodialysis and hemodiafiltration are of limited use, activated charcoal and its ...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles Children's Health March 2017 Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
Maintenance of phosphate balance is essential for life, and mammals have developed a sophisticated system to regulate phosphate homeostasis over the course of evolution. However, due to the dependence of phosphate elimination on the kidney, humans with decreased kidney function are likely to be in a positive phosphate balance. Phosphate excess has been well recognized as a critical factor in the pathogenesis of mineral and bone disorders associated with chronic kidney disease, but recent investigations have also uncovered toxic effects of phosphate on the cardiovascular system and the aging process.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
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