Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation

Exostosin-1 (Ext1) encodes a glycosyltransferase required for heparan sulfate (HS) chain elongation in HS-proteoglycan biosynthesis. HS chains serve as binding partners for signaling proteins, affecting their distribution and activity. The Wnt/ β-catenin pathway emerged as critical regulator of chondrogenesis. Yet, how EXT1 and HS affect Wnt/β-catenin signaling during chondrogenesis remains unexplored.

Source: Osteoarthritis and Cartilage - July 18, 2019 Category: Rheumatology Authors: X. Wang, F.M.F. Cornelis, R.J. Lories, S. Monteagudo Source Type: research