Anti-inflammatory effects of blueberry extract in microglial cells

Background: Microglia (MG), the immunocompetent cells of the CNS, respond to brain injury activating and modifying their morphology. Microglia can exist broadly between two different activation states, namely the classical (M1) and the alternative activated (M2) phenotype. The first one is characterized by the production of pro-inflammatory cytokines, in contrast, the latter is characterized by the production of anti-inflammatory cytokines (Kettenmann et al., Neuron. 2013; 77:10 –18). Blueberry is involved in the control of the redox state of the cell, cooperating with antioxidant mechanisms, whereas its anti-inflammatory activity is still poorly understood (Businaro et al., Curr.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Maria Giovanna De Caris, Elisa Maggi, Antonio Francioso, Maddalena Grieco, Luciana Mosca, Maria D'Erme, Alessandro Pinto, Patrizia Mancini, Rita Businaro Source Type: research