Long-term effects of the ketogenic diet on growth in children with resistant drug epilepsy and Glucose Transporter Type 1 Deficiency Syndrome

Introduction: The ketogenic diet (KD) is an effective therapeutic option for patients with drug-resistant epilepsy (EFR) and is the only therapy currently available for Glucose Transporter Type 1 Deficiency Syndrome (GLUT1-DS). Studies on long-term effects and, particularly, on growth are required.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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ConclusionsThis study demonstrates that attentional stability is impaired in children with epilepsy and/or ADHD. Bron–Lyon Attention Stability Test seems to be a sensitive test to detect attentional stability deficit in children with epilepsy and with attentional complaints who did not meet all criteria of ADHD.We propose that BLAST could be a useful clinical neuropsychological tool to assess attentional disorders in children.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 17 August 2019Source: Epilepsy &BehaviorAuthor(s): Anastasia Brodovskaya, Jaideep KapurAbstractMapping the circuits underlying the generation and propagation of seizures is critically important for understanding their pathophysiology. We review evidence to suggest that circuits engaged in secondarily generalized seizures are likely to be more complex than those currently proposed. Focal seizures have been proposed to engage canonical thalamocortical circuits that mediate primarily generalized absence seizures, leading to secondarily generalized tonic–clonic seizures. In addition...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionThe incidence of early poststroke seizures was overall rare, and no significant differences emerged between patients receiving and those not receiving reperfusion therapies.This article is part of the Special Issue “Seizures and Stroke”.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 17 August 2019Source: Epilepsy &BehaviorAuthor(s): Rhys H. Thomas, Karen OslandAbstractThe Epilepsy Deaths Register (EDR) differs from typical registries which concentrate primarily on clinical information. It is completed by bereaved relatives and focuses on the circumstances immediately before, and the support following, a death. It can be augmented by copies of death certificates from the families of the deceased, and all epilepsy associated deaths can be entered. The EDR is underpinned by the research and experience of the SUDEP Action team and the clinical advisors who helped des...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 17 August 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Maureen A. KaneAbstractA fast liquid chromatography-tandem mass spectrometry method using polarity switching and timed selected reaction monitoring has been developed and validated to quantify eight antiepileptic drugs and an active drug metabolite in human plasma within a single analytical assay. The antiepileptic drugs include levetiracetam, lamotrigine, zonisamide, topiramate, carbamazepine, phenytoin, divalproex sodium, oxcarbazepine, and the oxcarbazepine active metabolite 10,11-dihydro-10-hydroxycarbam...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): A. Skalnaya, V. Fominykh, R. Ivashchenko, D. Averchenkov, L. Grazhdantseva, N. Frigo, E. Negasheva, O. Dolya, L. Brylev, A. GuekhtAbstractThe term of neurosyphilis (NS) refers to infection of central nervous system by Treponema pallidum. Classically, it has been divided into early (meningitis, meningovascular) and late forms (general paresis and tabes dorsalis). The availability of penicillin and high sensitivity of Treponema pallidum to this antibiotic has led to a widely held perception about rarity of syphilitic forms wit...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
DiscussionWe showed that SD-EEG study confirmed a high specificity to assess a specific diagnosis. Therefore, the decrease of activity observed in DMN could be explain by a different amount of sleep/awake time during fMRI recording in the two groups or the interictal activity during fMRI acquisition. Our study highlighted alterated functional activity in SD cortical areas of epileptic patients if compared to HC.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsSeizures are important neurologic complications of SAH of all etiologies. Nevertheless, acute as well as remote symptomatic seizures are unrelated to the short-term outcome. These results should be treated as hypothesis generating and require confirmation.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 17 August 2019Source: Epilepsy &BehaviorAuthor(s): William Owen Pickrell, Michael Patrick KerrAbstractRoutinely collected data are a powerful research resource and offer the opportunity to further our understanding of epilepsy mortality and Sudden Unexpected Death in Epilepsy (SUDEP). The advantages of using routinely collected data include that it often covers whole populations, is already collected, and can be easily linked to other data sources. A significant disadvantage is the difficulty in obtaining accurate causes of death and correctly identifying cases of SUDEP. Using and lin...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue “Seizures &Stroke”
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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