Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS

Conclusion
Patients with extreme manifestations of CIS or early MS defined by strict MRI parameters can be best distinguished by combining markers of intrathecal B-cell accumulation and axonal damage. This could stratify individual treatment decisions toward a more personalized immunotherapy.

Source: Neurology Neuroimmunology and Neuroinflammation - July 18, 2019 Category: Neurology Authors: Engel, S., Friedrich, M., Muthuraman, M., Steffen, F., Poplawski, A., Groppa, S., Bittner, S., Zipp, F., Luessi, F. Tags: Multiple sclerosis Article Source Type: research