Intranasal Delivery of lincRNA-Cox2 siRNA Loaded Extracellular Vesicles Decreases Lipopolysaccharide-Induced Microglial Proliferation in Mice

In this study, we found thatlincRNA-Cox2 controls the expression of a set of cell cycle genes in lipopolysaccharide (LPS)-stimulated microglial cells. Our in vitro study suggested that knocking downlincRNA-Cox2 reversed LPS-induced microglial proliferation. In addition, our in vivo study demonstrated that intranasally delivered lincRNA-Cox2-siRNA loaded EVs could reach the brain resulting in a significant decrease in the expression oflincRNA-Cox2 in the microglia. Importantly, lincRNA-Cox2-siRNA loaded EVs also decreased LPS-induced microglial proliferation in mice. These findings indicate that intranasal delivery of EV-loaded small RNA could be developed as therapeutics for treatment of a multitude of CNS disorders.
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

.
Source: Anxiety, Stress and Coping - Category: Psychiatry & Psychology Authors: Source Type: research
.
Source: Educational Psychologist - Category: Psychiatry & Psychology Authors: Source Type: research
Bayer submits application to European Medicines Agency for pre-filled syringe to administer eye medication Eylea®mehr ...
Source: Bayer IR Newsfeed: Events - Category: Pharmaceuticals Source Type: news
Conclusion: New lesions at the reference MRI in terms of number and topography increase the risk of radiological disease activity during the follow up. PMID: 31959078 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
MiR-29a-3p/NID1 axis regulates pulmonary fibrosis induced by TGF-β1. Panminerva Med. 2020 Jan 20;: Authors: Lin L, Qu W, Li Y, Zhu H, Jiang W PMID: 31961112 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Zhang J, Guo Y, Jia T, Guo H, Meng F, Xue S PMID: 31961111 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Gao J, Zhao G, Wang P, Li S, Wang X, Zhao H PMID: 31961110 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang X, Wen Y, Xue L, Lu R, Tang H, Gao N, Zhang J, Xue Q PMID: 31961109 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Wang P, Xue L, Wang L, Tang H, Lv C, Xue Q PMID: 31961108 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Authors: Luan J, Liu Y, Liu H, Wang Z PMID: 31961114 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
More News: Brain | Drugs & Pharmacology | Genetics | Nanotechnology | Neurology | Study