Behcet's disease: A (silk) route to atrial fibrillation?

Atrial fibrillation (AF) is the most common sustained arrhythmia closely associated with inflammation [1]. AF development involves an array of electrophysiological and structural changes including shortened refractoriness, slow conduction, triggered activity, fibrosis, and enlarged atrial size, etc. as well as dysfunction of multiple ion channel proteins at either transcriptional or posttranslational levels [2]. Multiple canonical inflammatory signaling pathways including tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), and ‘NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome have been linked to arrhythmogenic mechanisms underlying AF development [1,3].

Source: International Journal of Cardiology - July 18, 2019 Category: Cardiology Authors: Santosh V. Suryavanshi, Na Li Tags: Editorial Source Type: research