Examination of pain threshold and neuropeptides in patients with acute suicide risk

In this study, we examined plasma peptides involved in analgesic and inflammatory responses and physical pain threshold in acutely suicidal patients.MethodsThirty-seven depressed patients of both sexes hospitalized for severe suicidal ideation or a recent suicide attempt were characterized clinically including history of suicidal ideation and behavior. Psychological and physical pain, and pressure pain threshold was also measured. Plasma levels of β-endorphin, neurotensin, agouti-related protein (AgRP), C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), and brain-derived neurotrophic factor (BDNF) were run in Milliplex multiplex assays.ResultsThe number of lifetime suicide attempts was positively correlated with β-endorphin (r = 0.702; p = 0.007), and neurotensin (r = 0.728, p = 0.007) plasma levels. Higher pain threshold was measured in the suicide attempt group as compared to the suicidal ideation group. Pain threshold was strongly and negatively associated with CRP plasma levels (r = −0.548; p 
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research

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Police officers are often the first responders when someone is having a mental illness crisis.  But are members of law enforcement properly equipped for this job?  There are plenty of horrifying stories that would indicate that the answer is “no.”  How do we change this?  Join us as Gabe speaks with Officer Rebecca Skillern from the Huston, Texas, Police Department about how Houston is training its officers to respond to these difficult calls. SUBSCRIBE &REVIEW   Guest information for ‘Policing and Crisis Intervention Training’ Podcast Episode   Officer Rebecca S...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Policy and Advocacy Relationships The Psych Central Show Source Type: blogs
BACKGROUND: Generalized anxiety disorder (GAD) and chronic pain conditions commonly co-occur, and are both independently associated with suicidality; however, little is known about the impact of chronic pain on suicidality among individuals with GAD. The a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Medications Professional Stigma Substance Abuse Effects Of Cannabis Legalizing Marijuana Psychosis Stigmatization Substance Use THC Source Type: news
Senator Joe Manchin (D-WV) and Mike Braun (R-IN) are still trying to address the fentanyl and heroin overdose crisis —soon to be joined by a methamphetamine and cocaine overdose crisis—by denying chronic pain patients access to pain relief. They have just introduced a bill they call The FDA Opioid Labeling Accuracy Act,  which would “prohibit the Food and Drug Administration (FDA) from allowing opioids to be labeled for intended use of ‘around-the-clock, long-term opioid treatment’ until a study can be completed on the long-term use of opioids.”Set aside the fact that most pain...
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Are there any good treatments for a lady on the inpatient unit that was admitted because of suicidal ideation due to chronic pain. She’s had many surgeries in the past and as a result has chronic pain all day only relieved by tons of opioids which were stopped by her pain medicine doc. She’s still on 7.5 mg Percocet 4x a day but that’s not enough she says. If her pain was manageable she would be able to move around the house and do stuff and be less depressed and suicidal but I can’t really... Suicidal pt due to chronic pain
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Veterans report chronic pain (CP) at two to three times the rates of civilians. Longer CP duration has been associated with negative health outcomes including depression, insomnia, and suicide. The insula, a critical node of the salience network, has been closely linked to the perception, and chronicity of pain. The current study utilized rs-fMRI imaging with insula as the seed region to examine insula connectivity associated with duration of pain.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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