Childhood atopic dermatitis: current developments, treatment approaches, and future expectations
Childhood atopic dermatitis: current developments, treatment approaches,
and future expectations
Turk J Med Sci. 2019 Jul 18;49(4):
Authors: Gür Çetinkaya P, Murat Şahiner Ü
Abstract
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder of childhood. Underlying factors that
contribute to AD are impaired epithelial barrier, alterations in the lipid composition of the skin, immunological imbalance including
increased Th2/Th1 ratio, proinflammatory cytokines, decreased T regulatory cells, genetic mutations, and epigenetic alterations. Atopic
dermatitis is a multifactorial disease with a particularly complicated pathophysiology. Discoveries to date may be considered the tip of
the iceberg, and the increasing number of studies in this field indicate that there are many points to be elucidated in AD pathophysiology.
In this review, we aimed to illustrate the current understanding of the underlying pathogenic mechanisms in AD, to evaluate available
treatment options with a focus on recently discovered therapeutic agents, and to determine the personal, familial, and economic burdens
of the disease, which are frequently neglected issues in AD. Currently available therapies only provide transient solutions and cannot
fully cure the disease. However, advances in the understanding of the pathogenic mechanisms of the disease have led to the production
of new treatment options, while ongoing drug trials also have had pro...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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