How do you determine the optimal biologic treatment for psoriasis?

How do you determine the optimal biologic treatment for psoriasis? Br J Dermatol. 2019 Jul 18;: Authors: Gardner R, Burden AD PMID: 31318044 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Condition:   Psoriasis Interventions:   Other: No intervention - Psoriasis Subject;   Other: No intervention - Control Subject Sponsor:   Wright State Physicians Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In a regulatory filing, Sun Pharmaceutical Industries said its "wholly-owned Japanese subsidiary has launched Ilumya Subcutaneous Injection 100 mg Syringe in Japan for the treatment of plaque psoriasis in adult patients who have an inadequate response to conventional therapies".
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to the aging research community because NAD is important to mitochondrial function. NAD levels diminish with age, alongside a loss of mitochondrial function that is known to contribute to the onset and progression of many age-related conditions. Animal studies and a few clinical trials have indicated that increased NAD levels may improve, for example, cardiovascular function in older individuals, as a result of improved mitochondrial functi...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This study provides characterization of a lipid-rich necrotic core, a dangerous type of coronary plaque made up of dead cells and cell debris that is prone to rupture. Ruptured plaque can lead to a heart attack or stroke. The analysis involved 209 middle-aged patients (ages 37-62) with psoriasis who participated in the Psoriasis Atherosclerosis Cardiometabolic Initiative at the National Institutes of Health, an ongoing observational study. Of these participants, 124 received biologic therapy, and 85 were in the control group, treated only with topical creams and light therapy. To measure the effects of biologic ther...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract Elevated cytokine levels in inflammatory diseases are associated with downregulation of certain cytochrome P450 (CYP) enzymes. Upon treatment with some cytokine-targeting therapeutic proteins, the CYP enzymes levels may be restored resulting in therapeutic protein-mediated drug interactions (TP-DI). These analyses characterized the worst-case scenario for CYP1A2, 2C9, and 3A-based TP-DI potential in patients with psoriasis by comparing the pharmacokinetics of probe substrates between healthy volunteers and subjects with moderate to severe psoriasis. Data for the CYP probe substrates midazolam (CYP3A), caf...
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research
CONCLUSIONS: Evidence is lacking for or against major chronic PPP treatments. Risk of bias and imprecision limit our confidence in the results. PMID: 32961599 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Condition:   Psoriasis Interventions:   Drug: Apremilast 30mg;   Drug: calcipotriene and betamethasone dipropionate Sponsor:   Derm Research, PLLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Psoriasis is a chronic inflammatory disease of the skin with multiple comorbidities, depression being one of them. Psoriasis affects the personal, social, and sexual lives of the patients resulting in psychological strain.   Psoriasis and depression amplif...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
MONDAY, Sept. 21, 2020 -- Myocardial infarction (MI) events may occur earlier in life in patients with psoriasis, which in turn may affect hospital outcomes, according to a study published online Sept. 11 in the Journal of the American Heart...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Condition:   Psoriasis Interventions:   Drug: Apremilast 30mg;   Drug: calcipotriene and betamethasone dipropionate Sponsor:   Derm Research, PLLC Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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