Multiple abscesses in a renal transplant recipient

A 30-year-old man who underwent renal transplantation 10 years ago presented with multiple painful swellings in his limbs and joints with limitation of movement (Supplementary Figure  S1), which had developed over 3 weeks. He was on dual immunosuppression with prednisolone and tacrolimus because of multiple infections in the past. He was normotensive and afebrile. Each swollen area was tender and fluctuant. His hemoglobin level was 7.3 g/dl; the total leukocyte count was 21,800 cells/mm3; and the serum creatinine level was 2.9 mg/dl.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research

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Pioneer UK surgeon Sir Terence English says adapted organs could transform treatmentAdapted pig hearts could be transplanted into patients within three years, according to a report citing the surgeon who pioneered heart transplantation in the UK.On the 40th anniversary of the first successful heart transplant, Sir Terence Englishtold The Sunday Telegraph that his protege from that operation would try to replace a human kidney with a pig ’s this year.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Heart attack Heart disease Science Society UK news Source Type: news
CONCLUSIONS: Pre-emptive transplantation can yield comparable outcomes to those for post-dialysis kidney transplantation, and results in better quality of life for patients with end-stage kidney disease, as well as a reduced cost. PMID: 31416631 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Sir Terence English, who performed Britain's first ever successful heart transplant, said his mentee from the 1979 operation will try to replace a human kidney with a pigs before the end of the year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This article presents two cases of post-KTx reactive HLH that underwent adjuvant IVIG treatment and obtained good clinical results. Despite the high morbidity and mortality associated with reactive HLH after KTx, the early and precise diagnosis and the administration of IVIG therapy along with the treatment of the triggering disease, was an effective strategy to control HLH. PMID: 31419275 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Authors: Foresto RD, Santos DWCL, Hazin MAA, Leyton ATZ, Tenório NC, Viana LA, Cristelli MP, Silva Júnior HT, Pestana JOM Abstract In 2004, a global spread of Chikungunya fever affected most tropical and subtropical regions of the world. In 2016, an outbreak occurred in Northeast Brazil with hundreds of cases documented. Solid organ transplant recipients have a modified immune response to infection and the clinical course is usually different from immunocompetent patients. The diagnosis can be challenging in this population. Most reports describe patients residing in endemic areas, although we must em...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Authors: Sánchez-Vicente JL, López-Herrero F, Martínez-Borrego AC, Lechón-Caballero B, Moruno-Rodríguez A, Molina-Socola FE Abstract A 32 year-old man who presented with severe elevation of blood pressure after failure of kidney transplant. The patient had multiple serous retinal detachments, venous dilation, arteriolar narrowing, retinal haemorrhages, as well as optic disc oedema. Due to the impossibility of performing a fluorescein angiography, an angiotomography and en-face optical coherence tomography images were used to identify the vascular alterations in the retina, choroid...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
Chronic inflammation in end-stage renal disease (ESRD) is partly attributed to gut bacterial translocation (GBT) due to loss of intestinal epithelium integrity. Increased levels of circulating lipopolysaccharide (LPS) –a surrogate marker of GBT– contribute to maintain a chronic inflammatory state. However, circulating LPS can be neutralized by lipoproteins and transported to the liver for elimination. While ESRD-associated GBT has been widely described, less is known about its changes and impact on clinical outcome after kidney transplantation (KT). One hundred and forty-six renal transplant recipients with ser...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: A simple, fast and reliable UPLC-MS/MS method to quantify MPA in plasma was validated and has been applied for pharmacokinetic analysis in kidney transplant patients. PMID: 31419321 [PubMed - as supplied by publisher]
Source: Biomedical Chromatography : BMC - Category: Biomedical Science Authors: Tags: Biomed Chromatogr Source Type: research
Kidney transplantation (KT) is the gold-standard treatment for end-stage renal disease (ESRD) in children. Robot-assisted kidney transplantation (RAKT) in adults is becoming increasingly common in centers of reference with promising results and potentially improved morbidity compared to open KT[1]. Our objective was to evaluate the feasibility, perioperative and 1-year postoperative outcomes of RAKT in children. To our knowledge, this is the first report of RAKT in a child. The technique is presented in our video.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Tags: Video Bank Source Type: research
Abstract Objective To assess maternal and perinatal outcomes in pregnancies after kidney transplantation in a tertiary center in Brazil. Methods Retrospective cohort of pregnancies in women with kidney transplantation at the Universidade Estadual de Campinas, from January 1995 until December 2017. Medical charts were reviewed, andmaternal and perinatal outcomes were described as means and frequencies. Renal function and blood pressure were evaluated during pregnancy and postpartum. Results A total of 22 women had at least 1 pregnancy during the considered timeinterval, and 3 of them had> 1 pregnancy, totalizing 25 pregn...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
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