Association of autoantibody quantification with systemic lupus erythematosus disease activity: comment on the article by Kim et al

Arthritis&Rheumatology, EarlyView.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Letters Source Type: research

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Background: Palisaded neutrophilic and granulomatous dermatitis (PNGD) classically occurs in association with systemic diseases, most commonly rheumatoid arthritis and systemic lupus erythematosus.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Expert Opinion on Therapeutic Targets - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractObjectiveDetermine the stage in B cell development that a Systemic Lupus Erythematosus (SLE) ‐associated DNA methylation signature originates in African American (AA) and European American (EA) individuals and assess its ability to predict SLE status in individual and mixed immune cells.MethodsB cells from AA (n = 31) and EA (n = 49) patients were sorted using fluorescence activated cell sorting (FACS) into five subsets. DNA methylation measured at ~460,000 CpG sites was interrogated in each subset. Enrichment analysis of transcription factor interaction at SLE ‐associated methylation sites was performed. A ran...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
In clinical practice, discrimination between central nervous system (CNS) infections in patients with systemic lupus erythematosus (SLE) and neuropsychiatric lupus erythematosus (NPSLE) could be urgent and cri...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
M. Yassine For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS), herpetic stromal keratitis (HSK), celiac disease (CD), and multiple sclerosis (MS). Best examples of viral infections that have been proposed to modulate the induction and development of autoimmune diseases are the infections with enteric viruses such as Coxsackie B virus (CVB) and rotavirus, as well as influenza A viruses (IAV), and herpesviruses. Other viruses that ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
CONCLUSIONS: There was no association between the PAI‑1 4G/5G polymorphism and SLE/LN and RA development and significantly higher levels of circulating PAI‑1 were observed in patients with SLE but not in those with RA. PMID: 31428858 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
Authors: Wang P, Mao YM, Liu LN, Zhao CN, Li XM, Pan HF Abstract A growing body of data suggests that semaphorins are involved in both normal and pathological immune responses, as well as autoimmune pathologies. To investigate the plasma semaphorin 3A (Sema3A) and semaphorin 7A (Sema7A) levels in systemic lupus erythematosus (SLE) patients and their correlation with clinical manifestations and laboratory indexes, a two-step method was applied. First, 80 SLE patients and 80 healthy controls were recruited for comparing serum Sema3A and Sema7A concentrations. Second, 40 rheumatoid arthritis (RA) patients and 40 sj&ou...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
CONCLUSION: Our study confirmed that general risk algorithms mostly underestimate and at times overestimate cardiovascular risk in rheumatic patients. We did not find studies that evaluated models for psoriasis or AS, which further demonstrates a need for research in these populations. PMID: 31416923 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
Publication date: Available online 12 August 2019Source: Pharmacological ResearchAuthor(s): Charalampos Skarlis, Nikolaos Marketos, Clio P. MavraganiAbstractThe use of biologic disease modifying antirheumatic drugs (bDMARDs) in systemic autoimmune diseases such as rheumatoid arthritis and at a lesser extent in lupus, has been well established. In Sjögren's syndrome (SS), despite the shared pathogenetic mechanisms with other autoimmune disorders, traditional immunomodulatory drugs have failed to address the main clinical features of the disease and use of biologics has been limited so far. Over the last years, our bett...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Abstract The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified as an inducer of follicle-stimulating hormone secretion. Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
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