Dosimetric Comparison of Biologically-Guided Radiotherapy and X-ray-Guided Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancer

Prostate-specific membrane antigen (PSMA)-targeted PET tracers have improved early detection of oligometastatic (OM) prostate cancer. Evidence suggests that stereotactic ablative radiotherapy (SABR) for OM prostate cancer may improve clinical outcomes, but localization of multiple small lesions for treatment is challenging with conventional X-ray-based imaging systems, limiting deliverable doses. Biologically-guided radiotherapy (BgRT) is being developed to utilize strong contrast of PET signal for real-time intra-fraction tracking of multiple targets.

Source: International Journal of Radiation Oncology * Biology * Physics - July 19, 2019 Category: Radiology Authors: W.T. Hrinivich, R. Phillips, A. Da Silva, N. Radwan, M. Gorin, S. Rowe, K. Pienta, M.G. Pomper, J.W. Wong, P.T. Tran, K.K.H. Wang Tags: Oral Abstracts Source Type: research