Keeping the autophagy tempo.

Keeping the autophagy tempo.
Autophagy. 2019 Jul 18;:
Authors: Pastore N, Ballabio A
Abstract
Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERBα, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.
PMID: 31318631 [PubMed - as supplied by publisher]

Source: Autophagy - July 17, 2019 Category: Cytology Authors: Pastore N, Ballabio A Tags: Autophagy Source Type: research