GSE134457 High-throughput sequencing analysis of BMMs and BMMs-derived osteoclasts

Contributors : Xiaogang Wang ; F Jin ; J Li ; M Cai ; R Wang ; C Ma ; M Liu ; J Zhong ; R Zhang ; J Xiao ; Z Wang ; X Ji ; Y Wang ; Y Zhang ; Y Sun ; X WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLong noncoding RNAs (lncRNAs) have emerged as integral regulators of physiology and disease, but specific roles of lncRNAs in bone resorption remain largely unknown. Here, RNA-seq analysis indicated that lncRNA Nron was a candidate funtional regulators of bone resorption. Our further experimental analysis showed that Nron regulates bone resorption in mice. We further identified a functional motif of Nron. Consequently, delivery of Nron functional motif specifically in osteoclasts reversed bone loss without obvious side-effects in vivo. Together, our study indicate that Nron is a key bone resorption suppressor and reveal Nron functional motif might be a potential therapeutic strategy to combat excessive bone absorption in osteoporosis.  
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research